Configurable scale-up columns

Prepacked columns with your preferred media

Scale purification with confidence. We prepack your preferred media into Biotage columns (Flash 75/150/400 - 400 gm to 40 kg) to maintain method continuity from development to large scale—fast, safe, and reproducible.

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Simplify chromatography scale-up with prepacked columns

Scaling chromatography from lab to pilot or manufacturing often introduces variability and delays. When preferred chromatography media is not available in prepacked columns at scale, teams are forced to rely on self-packed columns, which can add manual work and potential changes to purification methods during process optimization.

Biotage tailored scale-up columns simplify flash chromatography scale-up by helping you use the same media from development through larger-scale purification. Compatible with several types of media, the columns are precisely prepacked to reduce variability and support a smoother, more reliable scale-up process.

Formats

Flash 75, Flash 150 (M/L), Flash 400 (M/L)
Scale path

~5 g (development) → up to 40 kg columns (FL400L)
Media

Silica, alumina, ion exchange media, scavengers or your media if feasible

Small molecules, peptides, lipids, linkers, small molecules; including HP API workflows where safety and reproducibility at scale are critical.

1. Prequalification

We begin with a feasibility discussion to understand your media, purification goals, target scale, and required column format.
2. Proposal

Based on your requirements, we recommend a column configuration and provide a proposal outlining the setup, commercial terms, and when appropriate, a proof-of-concept evaluation.
3. Delivery

You receive ready-to-use prepacked columns, along with documentation packages to support your internal qualification and scale-up activities.

Synthesis

Purification

Evaporation

Sample extraction and clean-up

Bioanalysis and clinical testing

Forensic toxicology and doping control

Environmental testing

Food safety

Biomolecule purification

Peptides

Small molecules

Configurable scale-up columns

Specifications

Formats

Scale path

Media

1. Prequalification

2. Proposal

3. Delivery

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