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Isolera™ Prime

Advanced Automated Flash Purification

Flash Purification System Isolera Prime
Flash purification system Isolera Prime Flash Purification System Isolera Prime right

Isolera™ Prime is a value based system which recommends appropriate cartridges and calculates the best solvent conditions and gradients for your purifications. It has solvent pumps, automated fraction collection as standard and delivers much more than just the basics. Solvent use is minimized and advanced compound detection makes sure that your purified compound is delivered at the end of the run. We belive in providing value, so Isolera Prime systems embrace ACI™, a revolutionary advancement, converting regular flash from simple purification to the fastest, greenest, and most economical way to reliably isolate pure compounds for organic synthesis. ACI offerred as standard on Isolera Prime.

INSTRUMENTS

Part No. Description Product type Pack Size Price
ISO-PSF Isolera Prime system with 254nm detector and single collector bed Instruments 1 Log in for price
ISO-PSV Isolera Prime system with 200-400nm variable detector and single collector bed Instruments 1 Log in for price

ACCESSORIES

Part No. Description Product type Pack Size Price
411776 Column Holder SNAP 25g Accessories 1 Log in for price
411789 Rack 13 x 100 (4) - Isolera Accessories 1 Log in for price
411790 Rack 16 x 100 (4) - Isolera Accessories 1 Log in for price
411791 Rack 16 x 150 (4) - Isolera Accessories 1 Log in for price
411792 Rack 18 x 150 (4) - Isolera Accessories 1 Log in for price
411793 Rack 25 x 150 (4) - Isolera Accessories 1 Log in for price
411794 Rack 120mL (4) - Isolera Accessories 1 Log in for price
411922 Column Hold SNAP 10g - Isolera Accessories 1 Log in for price
411923 Column Hold SNAP 50-100g - Isolera Accessories 1 Log in for price
411924 Column Hold SNAP 340g - Isolera Accessories 1 Log in for price
411929 Tray, 480mL CPL (Sellable) - Isolera Accessories 1 Log in for price
411934 Tray, 240mL CPL (Sellable) - Isolera Accessories 1 Log in for price
412019 Isolera Instrument Tray w. Solvent Detector Accessories 1 Log in for price
413092 Biotage ZIP 5g/10g cartridge holder Accessories 1 Log in for price
413302 Biotage ZIP 30g cartridge holder Accessories 1 Log in for price
413303 biotage ZIP 45g cartridge holder Accessories 1 Log in for price
413304 Biotage ZIP 80g cartridge holder Accessories 1 Log in for price
413305 Biotage ZIP 120g cartridge holder Accessories 1 Log in for price

Isolera™ Prime

Is the new standard in value-priced flash purification systems delivering a full range of features and time and cost-saving benefits. This flexible entry level ACI™ Accelerated Chromatographic Isolation system is upgradeable and grows with the needs of laboratories and universities where value is especially important. Isolera Prime is compatible with Biotage flash cartridges, including the new value-priced Biotage ZIP®.

The Isolera Prime is specifically designed for chemists needing an automated purification platform to increase productivity delivering high value and just the right features.

Superior Results with Biotage Flash Cartridges 

Forget the rule of thumb. Isolera Prime systems recommend the optimal cartridge for the sample. 

Value

The entry level Isolera™ Prime delivers more than just the basics. Included as standard is a patented TLC-to-Gradient feature that eliminates method development guesswork and a solvent-saving gradient optimization function that reduces solvent use by up to 60%. Cost savings are further realized with use of the new value-priced, high performing Biotage ZIP cartridges available in wide range of sizes. 

Performance

Isolera™ Prime performs at flow rates upto 100 mL/min with a pressure range up to 145 psi (10 bars).  The built-in UV detector (a choice of dual wavelength or fixed options exist) provide excellent detection for aromatic and conjugated organic compounds and can trigger fractionation using threshold, slope, or volume parameters.

Method Editing 

Isolera methods may be created in many different ways.For small samples without TLC, open a default method and press run. For solvent intensive or larger samples, use the simple TLC to flash-gradient conversion tool.

Change your mind? Methods can easily be edited either on the touch screen or remotely from the comfort of your office. Edit by table or drag and drop, change flow rate, collection volume, fraction wavelengths, modes or add more collection racks if you need to – all while the run is in progress.  You can also use up to four solvents in a single gradient to easily purify samples with diverse polarity. 

Flexibility

Isolera™ Prime can be upgraded and customized to any laboratory’s requirements with the addition of a range of accessories, including external dry-loading vessels, leak detector, fraction racks and cartridge holders.  Biotage also offers the widest range of flash cartridges for higher performance and scalability including Biotage ZIP® and Biotage ZIP Sphere®, industry-standard Biotage SNAP®, gold Standard SNAP ULTRA®, and ISOLUTE® cartridge products.

Enhance productivity with on-the-fly editing

Isolera methods can easily be edited either in front of the Isolera or from the comfort of your office. Edit the gradient (click & drag points AND segments), flow rate, collection volume, fraction wavelengths and modes, and add more collection racks if you need to – all while the run is in progress. Gradient changes can now be made with a simplified graphical interface or through a table layout.

 

Features

  • Value based system with a full range of features
  • Solvent-saving Gradient Optimization can reduce solvent use up to 60% lowering system
  • Upgradeable and grows to your needs
  • 145 psi (10 bar) pressure capability enables both normal-phase and reversed-phase purification
  • Patented TLC-to-Gradient feature eliminates method development guessing and re-runs
  • Up to 100 mL/min flow rate to speed purification
  • Utilizes Biotage ZIP cartridges and high performance Biotage SNAP cartridges
  • Small footprint minimizes bench and hood space
  • Large 10.4 inch (26.4 cm) touchscreen with large buttons simplifies user interaction
  • Easy to use software enables fast method development
  • Two UV detector options to address different application needs
  • 4.8-L fraction capacity minimizes rack changes