ISOLUTE® Si-TMT metal scavenger

Palladium-catalyzed reactions are very popular in organic synthesis. Some of the most widely practiced examples include Suzuki-Miyaura cross coupling reactions, Heck reactions, Buchwald aminations, Wacker-type oxidation, hydrogenation, allylation, reductive deallylation and indole formation. Despite the widespread use of these palladium-mediated reactions, removal of residual palladium during workup and product isolation remains a major problem. Reducing the palladium content to the low parts per million (ppm) levels, as is required for active pharmaceutical ingredients, is particularly challenging. Biotage has developed a portfolio of scavenging products designed to remove these transition metal impurities. ISOLUTE® Si-TMT (along with MP-TMT, our polymeric resin variant) are some of the most powerful generic use metal scavengers available.

Literature number: PPS378