ISOLUTE® Si-Thiol metal scavenger

Palladium-catalysed reactions are very popular in organic synthesis. Some of the most widely practiced examples include Suzuki-Miyaura cross coupling reactions, Heck reactions, Buchwald aminations, Wacker-type oxidation, hydrogenation, allylation, reductive de-allylation and indole formation. Despite the widespread use of these palladium-mediated reactions, removal of residual palladium during workup and product isolation remains a major problem. Reducing the palladium content to the low parts per million (ppm) levels, as is required for active pharmaceutical ingredients, is particularly challenging. Biotage has developed a portfolio of scavenging products designed to remove these transition metal impurities. ISOLUTE® Si-Thiol was developed to address the need for a versatile metal scavenger that can be deployed in a multitude of different cases. It is the workhorse of the scavenging world and a first port of call for many screening and process applications. 

Literature number: PPS374