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Biotage^® MP-Cyanoborohydride

Powerful, Safe, and efficient cyanoborohydride chemistry for reductive amination

Biotage® MP-Cyanoborohydride is a macroporous polymer supported cyanoborohydride. It is a versatile reducing agent for the reductive amination of carbonyl compounds and reduction of imines. The reaction work-up protocol is greatly simplified by using the solid supported reagent. Specifically, compared with the small molecule sodium cyanoborohydride, it is reported that toxic cyanide is not released on reaction workup and therefore does not contaminate the product or pose a danger towards the user.

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Biotage® MP-Cyanoborohydride Product Note

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Part numbers

Part No.	Description	Pack Size	List Price
800408	Biotage® MP-Cyanoborohydride, 1 kg	1		Add to quote/cart
800405	Biotage® MP-Cyanoborohydride, 10 g	1	101 USD	Add to quote/cart
800407	Biotage® MP-Cyanoborohydride, 100 g	1	648 USD	Add to quote/cart
800406	Biotage® MP-Cyanoborohydride, 25 g	1	215 USD	Add to quote/cart
800511	Biotage® MP-Cyanoborohydride, 3 g	1	46 USD	Add to quote/cart

Specifications

CHEMICAL NAME Macroporous triethylammonium methylpolystyrene cyanoborohydride

RESIN TYPE Macroporous polystyrene

APPLICATION Reduction of carbonyl compounds, azides and oximes; reductive reduction of conjugated enones to unsaturated alcohols.

TYPICAL CONDITIONS FOR ALDEHYDE AND KETONE REDUCTION 1.0 mmol of carbonyl compound in ethanol or methanol and 0.5 mmol of MP-Borohydride stirred at room temperature for 2–12 h, depending on the nature of the carbonyl compound. Product isolated by filtration to remove the resin.

COMPATIBLE SOLVENTS THF (2.9 mL/g), DCM (3.4 mL/g), MeOH (3.4 mL/g), DMF (2.9 mL/g)

TYPICAL CONDITIONS FOR REDUCTIVE AMINATION 1.2 mmol of carbonyl compound, 1.0 mmol of primary or secondary amine in ethanol and 0.1 mL of acetic acid stirred for 4 h at room temperature, followed by 1.5 mmol of MP-Borohydride with gentle agitation overnight at room temperature. Product isolated by filtration to remove the resin.

STORAGE Closed container at 5 °C

SHELF-LIFE / RETEST DATE 5 years / typically annually thereafter depending on process

CAPACITY 2.5-3.5 mmol/g

PARTICLE SIZE 350-1250 microns

BULK DENSITY 500g /L

Biotage® MP-Cyanoborohydride Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.

Biotage® MP-Cyanoborohydride Product Note

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Efficiently deliver chemistry

More effective than traditional methods, polymer supported chemistry has been used widely in applications for over fifty years. Biotage supported reagents and scavengers are based on functionalized polystyrene or silica polymers and are 100% insoluble, therefore can be added to reactions and completely removed afterwards.

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Industry Proven

Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable and safe

From grams in research through to multi kilogram quantities in production campaigns. Compared with the small molecule sodium cyanoborohydride, toxic cyanide is not released on reaction workup and therefore does not contaminate the product or pose a danger towards the user.

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Fully Documented and Quality Assured

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.

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Biotage^® MP-Cyanoborohydride

Powerful, Safe, and efficient cyanoborohydride chemistry for reductive amination

Part numbers

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Specifications