BIOMARK002.183 - Scaling up with Metal Scavengers Social

Biotage^® MP-TMT

The Gold Standard for Metal Scavenging

Biotage® MP-TMT is a macroporous polystyrene-bound trimercaptotriazine, a resin bound equivalent of 2,4,6-trimercaptotriazine (TMT). MP-TMT scavenges residual palladium from catalyzed reactions (and also other metals). MP-TMT is an inert robust, low swelling adsorbent, which makes it ideal for restricted volume environments. Its unique pore structure provides metals greater access to its reactive sites resulting in more effective scavenging.

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Biotage® MP-TMT Product Note

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Benefits

For over 15 years Biotage has been guiding and leading the industry in metal scavenging and is the number 1 choice for processes worldwide. Clean, effective, simple and specific metal scavengers allow you to remove metal impurities whilst maximizing product recovery.

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Powerful metal scavenging

More effective than traditional methods, less energy intensive than distillation, less API loss compared to carbon, less time and risk of failed batches than recrystallization, operationally simple and designed for plug and play approaches, in fixed beds or batch stirring applications.

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Industry Proven

Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable

From grams in research through to multi kilogram quantities in production campaigns

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Fully Documented and Quality Assured

Lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement

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Part numbers

Part No.	Description	Pack Size	List Price
801472	Biotage® MP-TMT, 1 kg	1		Add to quote/cart
801469	Biotage® MP-TMT, 10 g	1	254 USD	Add to quote/cart
801471	Biotage® MP-TMT, 100 g	1	2011 USD	Add to quote/cart
801470	Biotage® MP-TMT, 25 g	1	578 USD	Add to quote/cart
801506	Biotage® MP-TMT, 3 g	1	107 USD	Add to quote/cart
K-MS-3	Metal Scavenging Screening Kit - SPE	1	192 USD	Add to quote/cart
K-MS-2	Metal Scavenging Toolkit - Batch	1	507 USD	Add to quote/cart

Literature

PRODUCT NOTE

Biotage^® MP-TMT Product Note

Key facts and figures and quick at a glance usage data

APPLICATION NOTE

Metal Scavengers and ICH Q3D, A Regulatory Perspective

This note highlights key issues and perspectives relating to the successful use of metal scavengers in pharma, under ICH Q3D

POSTER

New Applications of Ruthenium Scavenging

Next to palladium, ruthenium is the next most frequently used metal. It is much more difficult to remove from reactions. This poster highlights methods and approaches towards ruthenium mitigation.

POSTER

Metal Scavengers in Process Chemistry

This poster highlights advantages and helps to identify potential pitfalls associated with the application of metal scavengers in scale up and process SOPs.

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Specifications

CHEMICAL NAME Macroporous polystyrene-2,4,6trimercaptotriazine

RESIN TYPE Highly cross-linked macroporous poly(styrene-co-divinylbenzene)

APPLICATION Scavenging palladium from aqueous and non-aqueous solutions

TYPICAL SCAVENGING CONDITIONS 3–5 equivalents Biotage MP-TMT relative to palladium content, up to 24 h, room temperature

COMPATIBLE SOLVENTS THF (4.3 mL/g), dichloromethane (DCM) (3.8 mL/g), toluene (<4.9 mL/g), acetonitrile (ACN) (<4.6 mL/g), methanol (MeOH) (4.3 mL/g), water (3.7 mL/g)