Biotage^® MP-TsOH

In Mitsunobu, Suzuki and Heck reactions, it is often challenging to isolate pure products from the byproducts such as triphenylphosphine oxide and palladium. MP-TsOH columns can be used to purify these products when they contain a basic functional group. The reaction mixture is applied to the column and the product is retained by MP-TsOH. The byproducts can be easily removed with a methanol or DCM wash step. The product can then be released by eluting with 2 M ammonia in methanol.
MP-TsOH may also be used in cartridge applications to perform Catch-and-Release of amine derivatives in analogy to silica-derived SCX-2 columns

Key supplier to industry for over 15 years, used in numerous patents and cGMP process campaigns

From grams in research through to multi kilogram quantities in production campaigns.

The abrasion-resistant matrix has better handling characteristics and reduced transfer losses compared to other materials.

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.