Biotage^® MP-TsOH

Rapid Purification of Amines by Catch and Release, Solvent Exchange

Biotage® MP-TsOH resin is a sulfonated macroporous polystyrene resin and has been optimized for use as a bound reagent or scavenger resin for the synthesis of small molecules. The sulfonic acid groups in MP-TsOH are readily accessible for removal of basic compounds (e.g. primary, secondary, and tertiary amines) by quaternary salt formation.

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Biotage® MP-TsOH Product Note

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Part numbers

Part No.	Description	Pack Size	List Price
800464	Biotage® MP-TsOH, 1 kg	1	2738 USD	Add to quote/cart
800461	Biotage® MP-TsOH, 10 g	1	58 USD	Add to quote/cart
800463	Biotage® MP-TsOH, 100 g	1	271 USD	Add to quote/cart
800462	Biotage® MP-TsOH, 25 g	1	119 USD	Add to quote/cart
800498	Biotage® MP-TsOH, 3 g	1	40 USD	Add to quote/cart

Specifications

RESIN TYPE Highly cross-linked poly(styrene-codivinylbenzene)

CHEMICAL NAME Macroporous polystyrene sulfonic acid

APPLICATION Scavenging and catch-and-release of amines, acid catalysis

COMPATIBLE SOLVENTS DCM (3.0 mL/g), THF (3.1 mL/g), DMF (3.1 mL/g), MeOH (3.05 mL/g)

BULK DENISTY 400g /L

TYPICAL SCAVENGING CONDITIONS Approx. 2–3 equivalents of resin relative to amine, 0.5–1 h, 20 ˚C, or real time amine catch and release applications (seconds / minutes)

STORAGE Cool dry / closed container

SHELF-LIFE / RETEST DATE 5 years / typically annually thereafter depending on process

NOMINAL CAPACITY 3.7 mmol/g

PARTICLE SIZE 375-575 microns

Biotage® MP-TsOH Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.

MP-TsOH resin is a sulfonated macroporous polystyrene resin that is a resin-bound equivalent of p-toluenesulfonic acid (TsOH). The resin may be used as an equivalent to the strong cation-exchange resin, Amberlyst A-15 (Rohm and Haas). MP-TsOH has been optimized for use as a bound reagent or scavenger resin for the synthesis of small molecules. The sulfonic acid groups in MP-TsOH are readily accessible for removal of basic compounds (e.g. primary, secondary, and tertiary amines) by quartenary salt formation. In addition, MP-TsOH does not contain dark leachable impurities derived from over-oxidation of the polystyrene backbone observed in higher loading sulfonic acid resins

Biotage® MP-TsOH Product Note

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Wide Scope of Applications

In Mitsunobu, Suzuki and Heck reactions, it is often challenging to isolate pure products from the byproducts such as triphenylphosphine oxide and palladium. MP-TsOH columns can be used to purify these products when they contain a basic functional group. The reaction mixture is applied to the column and the product is retained by MP-TsOH. The byproducts can be easily removed with a methanol or DCM wash step. The product can then be released by eluting with 2 M ammonia in methanol.
MP-TsOH may also be used in cartridge applications to perform Catch-and-Release of amine derivatives in analogy to silica-derived SCX-2 columns

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Industry Proven

Key supplier to industry for over 15 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable and avoiding the need for problematic work-ups

From grams in research through to multi kilogram quantities in production campaigns.

The abrasion-resistant matrix has better handling characteristics and reduced transfer losses compared to other materials.

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Fully Documented and Quality Assured

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.

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Biotage^® MP-TsOH

Rapid Purification of Amines by Catch and Release, Solvent Exchange

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Specifications