Biotage® MP-TsOH
Resin-bound acid
Sulfonated macroporous polystyrene resin, optimized for use as a bound reagent or scavenger resin for the synthesis of small molecules.
Biotage® MP-TsOH resin is a sulfonated macroporous polystyrene resin that is a resin-bound equivalent of p-toluenesulfonic acid.
The sulfonic acid groups in Biotage® MP-TsOH are readily accessible for removal of basic compounds (e.g. primary, secondary, and tertiary amines) by quaternary salt formation. it also provides a useful alternative to quenching reactions with aqueous or soluble organic acids.
With lot control, QA/QC documentation, SDS, ISO 9001/14001 registration, BSE/TSE statement and shelf-life statement, Biotage® MP-TsOH also supports the audit trail.
Specifications
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Resin type
Highly cross-linked poly(styrene-codivinylbenzene)
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Chemical name
Macroporous polystyrene sulfonic acid
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Application
Scavenging and catch-and-release of amines, acid catalysis
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Compatible solvents
DCM (3.0 mL/g), THF (3.1 mL/g), DMF (3.1 mL/g), MeOH (3.05 mL/g)
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Bulk density
400 g/L
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Typical scavenging conditions
Approx. 2–3 equivalents of resin relative to amine, 0.5–1 h, 20 ˚C, or real time amine catch and release applications (seconds / minutes)
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Storage
Cool dry / closed container
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Shelf-life / retest date
5 years / typically annually thereafter depending on process
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Nominal capacity
3.7 mmol/g
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Particle size
375-575 microns
Ordering information
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