BIOMARK002.183 - Scaling up with Metal Scavengers Social

ISOLUTE^® Si-Thiol

Diverse Metal Scavenger, A Work-Horse, Suitable for a Wide Range of Applications

ISOLUTE® Si-Thiol is the silica-bond equivalent of 1-propanethiol, whose main application is the scavenging of a variety of metals used in organic chemistry including Pd, Pt, Cu, Hg, Ag and Pb.

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ISOLUTE® Si-Thiol Product Note

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Benefits

For over 15 years Biotage has been guiding and leading the industry in metal scavenging and is the number 1 choice for processes worldwide. Clean, effective, simple and specific metal scavengers allow you to remove metal impurities whilst maximizing product recovery.

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Powerful metal scavenging

More effective than traditional methods, less energy intensive than distillation, less API loss compared to carbon, less time and risk of failed batches than recrystallization, operationally simple and designed for plug and play approaches, in fixed beds or batch stirring applications.

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Industry Proven

Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable

From grams in research through to multi kilogram quantities in production campaigns

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Fully Documented and Quality Assured

Lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement

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Part numbers

Part No.	Description	Pack Size	List Price
180-0100-D	ISOLUTE® Si-Thiol 1 g/15 mL	20	121 USD	Add to quote/cart
180-0100-C	ISOLUTE® Si-Thiol 1 g/6 mL	30	165 USD	Add to quote/cart
9180-1000	ISOLUTE® Si-Thiol 1 kg	1	1207 USD	Add to quote/cart
180-0050-B	ISOLUTE® Si-Thiol 500 mg/3 mL	50	204 USD	Add to quote/cart
180-0050-BG	ISOLUTE® Si-Thiol 500 mg/3 mL (Tabless)	50	219 USD	Add to quote/cart
180-0050-C	ISOLUTE® Si-Thiol 500 mg/6 mL	30	139 USD	Add to quote/cart
9180-0010	ISOLUTE® Si-Thiol, 10 g	1	64 USD	Add to quote/cart
9180-0100	ISOLUTE® Si-Thiol, 100 g	1	414 USD	Add to quote/cart
9180-0025	ISOLUTE® Si-Thiol, 25 g	1	104 USD	Add to quote/cart
9180-0500	ISOLUTE® Si-Thiol, 500 g	1	1844 USD	Add to quote/cart
K-MS-3	Metal Scavenging Screening Kit - SPE	1	184 USD	Add to quote/cart
K-MS-2	Metal Scavenging Toolkit - Batch	1	485 USD	Add to quote/cart

Literature

PRODUCT NOTE

ISOLUTE^® Si-Thiol Product Note

Key facts and figures and quick at a glance usage data

APPLICATION NOTE

Metal Scavengers and ICH Q3D, A Regulatory Perspective

This note highlights key issues and perspectives relating to the successful use of metal scavengers in pharma, under ICH Q3D

POSTER

New Applications of Ruthenium Scavenging

Next to palladium, ruthenium is the next most frequently used metal. It is much more difficult to remove from reactions. This poster highlights methods and approaches towards ruthenium mitigation.

POSTER

Metal Scavengers in Process Chemistry

This poster highlights advantages and helps to identify potential pitfalls associated with the application of metal scavengers in scale up and process SOPs.

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Specifications

CHEMICAL NAME Silica 1-propanethiol; 3-Mercaptopropyl silica gel (Si-Thiol; Si-SH)

RESIN TYPE Bioanalytical grade silica

APPLICATION Metal scavenger (e.g., Pd, Pt, Cu, Hg, Ag and Pb), scavenger of electrophiles eg. alkyl-, benzyl- and allyl- halides, acid chlorides, isocyanates

TYPICAL SCAVENGING CONDITIONS Add 3-5 equiv. Stir for 15 min-2 h, then filter, also amenable to fixed bed metal scavenging approaches

COMPATIBLE SOLVENTS Methanol (MeOH), Dichloromethane (DCM), Acetonitrile (MeCN), Acetone, Ethyl Acetate (EtOAc), N,N-Dimethylformamide (DMF), Dimethylsulfoxide (DMSO)