ISOLUTE® Si-Trisamine is a silica bound propyl-tris(2-aminoethyl)-amine. Si-Trisamine is a very powerful scavenger of electrophiles from aqueous or organic solutions as well as an effective scavenger for transition metals (+II oxidation states).
For over 15 years Biotage has been guiding and leading the industry in metal scavenging and is the number 1 choice for processes worldwide. Clean, effective, simple and specific metal scavengers allow you to remove metal impurities whilst maximizing product recovery.
More effective than traditional methods, less energy intensive than distillation, less API loss compared to carbon, less time and risk of failed batches than recrystallization, operationally simple and designed for plug and play approaches, in fixed beds or batch stirring applications.
Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns
From grams in research through to multi kilogram quantities in production campaigns
Lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
495-0100-D | ISOLUTE® Si-Trisamine 1 g/15 mL (20/pk) | 20 | 130 USD | Add to quote/cart |
9495-1000 | ISOLUTE® Si-Trisamine, 1 kg | 1 | Add to quote/cart | |
9495-0010 | ISOLUTE® Si-Trisamine, 10 g | 1 | 126 USD | Add to quote/cart |
9495-0100 | ISOLUTE® Si-Trisamine, 100 g | 1 | 502 USD | Add to quote/cart |
9495-0025 | ISOLUTE® Si-Trisamine, 25 g | 1 | 183 USD | Add to quote/cart |
9495-0500 | ISOLUTE® Si-Trisamine, 500 g | 1 | 2325 USD | Add to quote/cart |
K-MS-3 | Metal Scavenging Screening Kit - SPE | 1 | 192 USD | Add to quote/cart |
K-MS-2 | Metal Scavenging Toolkit - Batch | 1 | 507 USD | Add to quote/cart |
Key facts and figures and quick at a glance usage data
This note highlights key issues and perspectives relating to the successful use of metal scavengers in pharma, under ICH Q3D
Next to palladium, ruthenium is the next most frequently used metal. It is much more difficult to remove from reactions. This poster highlights methods and approaches towards ruthenium mitigation.
This poster highlights advantages and helps to identify potential pitfalls associated with the application of metal scavengers in scale up and process SOPs.
Metal scavengers are a clean and very effective way to remove metal residues from reaction products at trace levels. Perfect for any chemical laboratory working in regulated environments. Product Manager Sunil Rana, Ph.D., gives the metal scavenger tour in this video.
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Biotage is a global supplier and solutions partner to a wide range of customers within drug discovery and development and analytical testing. With strong expertise in separation and purification technologies, and a focus on leveraging intelligent workflow solutions, we aim to efficiently support the advancement and protection of human health.
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