Showing posts written by Jillian Neifeld
We’ve all heard about Synthetic Opioids and how frequently they’re being abused, creating an Opioid Epidemic. What many of us aren’t hearing about are other synthetic compounds that are out there. Syn...
Novel Psychoactive Substances (NPSs) are drugs that have been made to have similar effects to common drugs of abuse. For example, synthetic opioids like fentanyl were created to make the user think th...
Urine hydrolysis is a part of sample preparation that we do to eliminate glucuronides before urine analysis. So first, what are glucuronides? And why do we want to get rid of them? In this post, I’ll ...
One of the key features of the so called "in-well hydrolysis" is that it can be a time saver for high throughput labs, which makes it look very appealing. In this blog post, I will be discussing some ...
LC/MS/MS seems to be the gold standard in sample analysis nowadays. However, some labs are still analyzing samples using GC/MS. The majority of published peer-reviewed articles are for LC/MS/MS, so th...
In this blog post, we will discuss how to determine the optimal sample volume for a sorbent bed mass. We have developed an adequate solid phase extraction method for our laboratory. However, we're sta...
Solid-phase extractions (SPE) can be a long and sometimes complicated process. So, we want to make sure that everything works the first time we extract. In this blog post, I will be discussing some of...
It happens to all of us. We're getting a new method developed and validated and then it comes time to run our negative urines. And everything comes up as positive! There are peaks for our analytes of ...
Let's face it, the whole solid phase extraction method development process can be time consuming and expensive. So Dilute-and-Shoot methods end up being the choice in some laboratories. The problem is...
Synthetic cannabinoids are some of the most widely abused drugs in the world. They are structurally similar and have similar effects to marijuana but are frequently referred to as “legal highs”. Chemi...