Normal phase flash chromatography has been widely adopted as the most popular method of choice for separation of product mixtures and reaction by-products. Biotage supplies pre-packed purification cartridges featuring HP-Sphere 25 micron spherical silica (previously called ULTRA, in the SNAP ULTRA range) for a range of Biotage development and scale up flash purification platforms to support different chemistries and scale up purification scenarios. These cartridges are also used in validated cGMP processes worldwide. HP-Sphere provides the same benefits of a high surface area precision stationary phase, but the 25 micron average particle size diameter results in even tighter bands and higher resolution than similar larger sized silica. h has higher surface area and higher loading capacity than traditional amorphous (irregular) silica stationary phases. This stationary phase is very versatile and tuned for demanding larger scale applications where high sample loading and more precision is a requirement.
Use the cartridge selector below to quickly identify compatible cartridges for your purification platform and / or view available cartridges by size. Development and process development scale cartridges intended for use on Biotage® Selekt or our larger scale development platform Biotage® Isolera LS connect to the system via universal Luer-lock style connectors. Cartridges for our larger process development and scale up systems Biotage® Flash 75 / Flash 150 or Flash 400 systems require a compression module which is provided with the system, or available as a spare part (links open in a new window).
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SEL-2EV - Two Channel, Extended Collection Bed, UV Detector