Syro XP software controls the instrument functions and calculates all amounts and volumes of amino acids and reagents required. Each cycle of the synthesis can receive a completely different protocol. This flexibility allows not only single or multiple couplings, but also complete freedom in the choice of coupling strategies within any synthesis cycle.
Pre-activation of the amino acids can be performed for all the synthesis cycles or just for individual ones. The amino acids can be activated in parallel or individually directly prior to their distribution.
The Tip Synthesis option is designed for applications that require large numbers of peptides in small quantities (1–5 μmol). Each Tip Synthesis Module can be used to synthesize up to 96 peptides at a time. Each peptide is synthesized in a 0.4 ml tip with PE frit where accurate dispensing of reagents is essential. The Syro I system can accommodate 1 Tip Synthesis Module, and the Syro II system can accommodate 3–6 modules, allowing up to 576 peptides to be made at the same time.
The left arm is equipped with a pipette tip that is connected to a dosing pump via a tube and a three-way valve. All of the reagents defined on the work area can be sampled by the left arm and delivered to any chosen container on the work area. Additionally, the left arm can take in a solvent from outside the work area via the three-way valve and also deliver it to any reachable container.
The right arm possesses a triple pipetting comb in which every single pipette tip is attached to a dosing pump via a tube and a three-way valve. The pumps take up washing solutions and reagents from storage containers outside of Syro through the valve and the distributor. All wash steps and simultaneous reagent distribution, for example piperidine distribution, can be carried out by the right arm.