Showing posts tagged with "clinical-forensic-and-doping-testing"
Evaporation is often used during preparation of oligonucleotide samples before LC-MS/MS to remove excess solvents, buffers, or volatile reagents. By concentrating the sample and exchanging it into a m...
Bioanalysis involves sample preparation techniques designed to meet rigorous standards for sensitivity, specificity, accuracy, and precision. The standards are crucial for evaluating the safety and ef...
New, novel benzodiazepines have become some of the most abused unique psychoactive substances seen today. In the United States, these compounds are not approved for prescription use. Therefore, the de...
In post-mortem cases, where drugs or pesticides have been used for their poisonous properties, traditional matrices such as urine and whole blood may be inappropriate for qualitative and quantitative ...
With prescription abuse rising concomitantly with licit pain management, the need to expand a wider degree of drug monitoring within a single method has been increasingly sought after. With the incide...
Solid-phase extraction is generally regarded as the gold standard when comparing sample preparation approaches. However, SPE processing can be laborious and time consuming. In most cases you are requi...
Most drugs, both licit and illicit, are excreted in urine as glucuronide conjugates. Hydrolysis using beta-glucuronidase converts the glucuronidated metabolites back to their “free” or non-conjugated ...
Traditionally the analysis of aldosterone and angiotensin (for plasma renin activity measurement) are performed separately. However, the relationship of the aldosterone-to-renin-ratio is a very useful...
Whole blood continues to be a valuable tool in forensic toxicology for the immediate and near-term detection of illicit drugs, and in cases where no other sample is available. Screening drugs of abuse...
Miniaturisation within various fields of analytical chemistry is not a new phenomenon. Early phase small animal drug trials have largely been the driver due to limited sample sizes available. However,...