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Biotage^® MP-Borohydride

Versatile supported borohydride based reducing agent, no aqueous work-up required

Biotage® MP-Borohydride is a versatile reducing agent used for the reduction of carbonyl compounds and imines, and the reductive amination of aldehydes and ketones.

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Biotage® MP-Borohydride Product Note

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Specifications

CHEMICAL NAME Macroporous triethylammonium methylpolystyrene borohydride

RESIN TYPE Macroporous polystyrene

APPLICATION Reduction of carbonyl compounds, azides and oximes; reductive reduction of conjugated enones to unsaturated alcohols.

TYPICAL CONDITIONS FOR ALDEHYDE AND KETONE REDUCTION 1.0 mmol of carbonyl compound in ethanol or methanol and 0.5 mmol of MP-Borohydride stirred at room temperature for 2–12 h, depending on the nature of the carbonyl compound. Product isolated by filtration to remove the resin.

COMPATIBLE SOLVENTS THF (2.9 mL/g), DCM (3.4 mL/g), MeOH (3.4 mL/g), DMF (2.9 mL/g)

TYPICAL CONDITIONS FOR REDUCTIVE AMINATION 1.2 mmol of carbonyl compound, 1.0 mmol of primary or secondary amine in ethanol and 0.1 mL of acetic acid stirred for 4 h at room temperature, followed by 1.5 mmol of MP-Borohydride with gentle agitation overnight at room temperature. Product isolated by filtration to remove the resin.

STORAGE Closed container at 5 °C

SHELF-LIFE / RETEST DATE 1 year

CAPACITY 2.5-3.5 mmol/g

PARTICLE SIZE 350-1250 microns

BULK DENSITY 500g /L

Biotage® MP-Borohydride Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.

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Efficiently deliver chemistry

More effective than traditional methods, polymer supported chemistry has been used widely in applications for over fifty years. Biotage supported reagents and scavengers are based on functionalized polystyrene or silica polymers and are 100% insoluble, therefore can be added to reactions and completely removed afterwards.

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Industry Proven

Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable

From grams in research through to multi kilogram quantities in production campaigns

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Fully Documented and Quality Assured

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.

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Biotage^® MP-Borohydride

Versatile supported borohydride based reducing agent, no aqueous work-up required

Part numbers

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Specifications