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Biotage^® MP-Triacetoxyborohydride

Powerful Supported Triacetoxyborohydride for Reductive Amination

Biotage® MP-Triacetoxyborohydride is a macroporous polystyrene-supported equivalent of tetraalkylammonium triacetoxyborohydride. Its primary applications in the reductive amination of aldehydes and ketones under neutral or mildly acidic reaction conditions. This resin was developed to perform in a manner similar to that of the well-established sodium triacetoxyborohydride, while simplifying reagent handling and product purification. Moreover, for many of these reactions, a scavenger resin may be added for one-pot purification of the product.

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Biotage® MP-Triacetoxyborohydride Product Note

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Part numbers

Part No.	Description	Pack Size	List Price
800416	Biotage® MP-Triacetoxyborohydride, 1 kg	1		Add to quote/cart
800413	Biotage® MP-Triacetoxyborohydride, 10 g	1	202 USD	Add to quote/cart
800415	Biotage® MP-Triacetoxyborohydride, 100 g	1	1337 USD	Add to quote/cart
800414	Biotage® MP-Triacetoxyborohydride, 25 g	1	415 USD	Add to quote/cart
800517	Biotage® MP-Triacetoxyborohydride, 3 g	1	95 USD	Add to quote/cart

Specifications

RESIN TYPE Macroporous polystyrene, MP-Triacetoxyborohydride is stabilized with 10% THF by weight

APPLICATION Reductive amination with primary and secondary amines

COMPATIBLE SOLVENTS THF (2 mL/g), DMF (2 mL/g), N-methyl pyrrolidinone (NMP) (2 mL/g)

CHEMICAL NAME Macroporous triethylammonium methylpolystyrene triacetoxyborohydride

BULK DENISTY 500g /L

TYPICAL CONDITIONS FOR REDUCTIVE AMINATION 1.0 mmol of carbonyl compound, 1.2 mmol of primary or secondary amine in THF, and 2.5 mmol of the resin stirred overnight at room temperature.

STORAGE Closed container at 5 °C

SHELF-LIFE / RETEST DATE 1 year

CAPACITY 2.0 mmol/g

PARTICLE SIZE 350-1250 microns

Biotage® MP-Triacetoxyborohydride Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.

Biotage® MP-Triacetoxyborohydride Product Note

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Efficiently deliver chemistry

More effective than traditional methods, polymer supported chemistry has been used widely in applications for over fifty years. Biotage supported reagents and scavengers are based on functionalized polystyrene or silica polymers and are 100% insoluble, therefore can be added to reactions and completely removed afterwards. MP-Triacetoxyborohydride contains approximately 10% tetrahydrofuran (THF) by weight and consists of large spherical beads which, unlike sodium triacetoxyborohydride, are easy to weigh out, not air sensitive and can be manipulated with standard weighing tools. The resin is shelf stable for over 1 year and is not temperamental.

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Industry Proven

Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable and safe

From grams in research through to multi kilogram quantities in production campaigns. Compared with the small molecule sodium cyanoborohydride, toxic cyanide is not released on reaction workup and therefore does not contaminate the product or pose a danger towards the user.

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Fully Documented and Quality Assured

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.

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Biotage^® MP-Triacetoxyborohydride

Powerful Supported Triacetoxyborohydride for Reductive Amination

Part numbers

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Specifications