Isolera™ LS

Automated flash chromatography system for process development and production

Reliable and robust flash purification system for scale-up laboratories, featuring advanced software capabilities and designed to handle samples of up to 150 g per run.

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Up to 30% solvent savings with Gradient Optimization

Isolera™ Spektra software provides gradient optimization and builds a gradient to separate all the compounds (up to 6) in the sample. It also provides cartridge selection guidance based on the cartridge loading capacity and purification speed. The step gradient can also be used to isolate a targeted compound, reducing run time and solvent use further.

Elute complex samples with the Quatro-binary gradient

Use up to four solvents in a single gradient to easily purify samples with diverse polarity. With Quatro-binary gradient capability, traditional binary gradients with a limited polarity range can be adjusted to elute very lipophilic and highly polar compounds within a single purification.

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Improve fraction and compound purity

PDA scanning and λ-All technology detects any UV absorbing compound eluting from a flash cartridge, while measuring and displaying each eluting compound’s individual UV spectrum. Combined with novel baseline rise correction, yield losses to improper wavelength selection and large fraction volumes are no longer a concern.

Dimensions

565 mm (22”) x 596 mm (23.5”) x 497 mm (19.6”) (expanded bed)
Fraction collection modes

Volume, threshold, threshold with volume, low slope, medium slope
Flow rate range

50 – 500 mL/min

Weight

40 kg (88 lbs) typical, depending on configuration
Solvent delivery

Two constant volume (11-mL) electric HPFC pumps
Power requirements

100 – 240 VAC, 50/60 Hz, 4.0 A
Collection vessels

Test tubes (13, 16, 18, and 25 mm) and bottles (120 mL, 240 mL)
UV detection

Choice of variable wavelength (200–400 nm) or UV-VIS (200–800 nm
UV collection modes

Single/dual/λ-All wavelengths (variable UV and UV-VIS)

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Successful flash chromatography

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Ordering information

Part no.

SER-ISLS-FYMP

Name

First Year Maintenance Package - Isolera™ LS

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Part no.

SER-ILS1-IN

Name

Installation and Familiarization - Isolera™ LS

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Part no.

ISO-1LSV

Name

Isolera™ LS, One Channel, Extended Collection Bed, 200-400 nm Detector

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Part no.

ISO-1LSW

Name

Isolera™ LS, One Channel, Extended Collection Bed, 200-800 nm UV-VIS Detector

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Synthesis

Purification

Evaporation

Sample extraction and clean-up

Bioanalysis and clinical testing

Forensic toxicology and doping control

Environmental testing

Food safety

Biomolecule purification

Peptides

Small molecules

Isolera™ LS

Scale-up your flash purifucation

Up to 30% solvent savings with Gradient Optimization

Elute complex samples with the Quatro-binary gradient

Improve fraction and compound purity

Specifications

Dimensions

Fraction collection modes

Flow rate range

Weight

Solvent delivery

Power requirements

Collection vessels

UV detection

UV collection modes

Resources

White paper

Ordering information

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