Biotage® PS-TBD
Polymer-supported base
A powerful non-nucleophilic guanidine base for alkyation and C-C bond formation.
Biotage® PS-TBD is a polymer-supported base, which consists of a bicyclic guanidine moiety anchored on polystyrene.
Biotage® PS-TBD resin can facilitate Williamson ether synthesis at room temperature using very mild conditions, as it is effective at deprotonating moderately acidic hydrogen. The resin may also be used for the N-alkylation of aryl halides, esterification of carboxylic acids, and alkylation of acidic methylenes.
With lot control, QA/QC documentation, SDS, ISO 9001/14001 registration, BSE/TSE statement and shelf-life statement, Biotage® PS-TBD also supports the audit trail.
Specifications
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Resin type
1% Cross-linked poly(styrene-codivinylbenzene)
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Chemical name
1,5,7-triazabicyclo[4.4.0]dec-5-ene polystyrene
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Application
Alkylation of phenols and amines; esterification of carboxylic acids using alkyl halides; alkylation of activated methylene compounds; dehalogenation of organic halides; high throughput synthesis of aryl triflates and aryl nonaflates; Williamson ether synthesi
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Compatible solvents
Dichloromethane (DCM), Acetonitrile (MeCN), Acetone, Ethyl Acetate (EtOAc), N,N-Dimethylformamide (DMF), Dimethylsulfoxide (DMSO)
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Bulk density
350g /L
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Typical conditions
Conditions:2–3 equiv. relative to limiting reagent
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Storage
Cool dry / closed container
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Shelf-life / retest date
5 years / typically annually thereafter depending on process
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Nominal capacity
1.3 mmol/g
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Particle size
75-150 microns
Ordering information
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