Biotage® PS-Benzaldehyde resin is useful for removing nucleophiles from solution, including primary amines (selectively, even in the presence of secondary amines), hydrazines also carbon-based nucleophiles such as Meldrum’s acid and organometallics.
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
800363 | Biotage® PS-Benzaldehyde, 1 kg | 1 | Add to quote/cart | |
800360 | Biotage® PS-Benzaldehyde, 10 g | 1 | 107 USD | Add to quote/cart |
800362 | Biotage® PS-Benzaldehyde, 100 g | 1 | 698 USD | Add to quote/cart |
800361 | Biotage® PS-Benzaldehyde, 25 g | 1 | 227 USD | Add to quote/cart |
800502 | Biotage® PS-Benzaldehyde, 3 g | 1 | 46 USD | Add to quote/cart |
Key facts and figures and quick at a glance usage data
For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.
PS-Benzaldehyde is the resin-bound equivalent of benzaldehyde. This resin is useful for scavenging various nucleophiles, including primary amines (selectively compared with secondary amines), hydrazines also carbon-based nucleophiles such as Meldrum’s acid and organometallics. The capacity of the resin is typically 1.2 mmol/g, based on uptake of phenylhydrazine. Scavenging reactions typically use 3 equivalents of resin per equivalent of substrate to be scavenged. Various solvents can be used, including DCE, DCM, and DMF with a typical temperature range from 20 to 50 ˚C. PS-Benzaldehyde is stable at room temperature with no loss of activity observed.
Phenylhydrazine Scavenging: PS-Benzaldehyde resin (3 equivalents) in DCE was allowed to react with phenylhydrazine (1 equivalent) in the presence of a catalytic amount of glacial HOAc. The reaction was monitored by TLC and was complete after stirring for approximately 1 h at room temperature. The reaction may also be run without HOAc by heating for 1 h at 50 ˚C.
Scavenging Various Nucleophiles: PS-Benzaldehyde (3 equivalents) was added to a solution of the substrate in DCE along with a catalyst if necessary. The mixture was stirred for the specified time and temperature, and the filtrate was analyzed by TLC for disappearance of the substrate by comparison with standards.
Reductive Alkylation of Primary Amines. A THF solution (0.50 M) of N-(3-aminopropyl)morpholine (1.2 mL, 0.60 mmol) was added to a THF solution (0.50 M) of 1,4-cyclohexanedione mono-ethylene ketal (1.0 mL, 0.50 mmol). MP-Triacetoxyborohydride (2.0 mmol/g, 0.625 g, 1.25 mmol) was then added and the mixture was agitated for 16 h at room temperature. When the reaction was complete, PS-Benzaldehyde (0.42 g, 0.5 mmol) and THF (2 mL) were added and the mixture was further agitated for 6 h. The resin was filtered and washed with THF (2 x 4 mL). The combined solution was concentrated to afford the product secondary amine as the acetate salt in high yield and purity.
Key supplier to industry for over 15 years, used in numerous patents and cGMP process campaigns
From grams in research through to multi kilogram quantities in production campaigns.
The abrasion-resistant matrix has better handling characteristics and reduced transfer losses compared to other materials.
Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.
SEL-2EV - Two Channel, Extended Collection Bed, UV Detector
Biotage is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in drug discovery and development and diagnostics, analytical testing and water and environmental testing.
Biotage is contributing to sustainable science with the goal to make the world healthier, greener and cleaner – HumanKind Unlimited.
Our customers span a broad range of market segments including pharmaceutical, biotech, diagnostic, contract research and contract manufacturers as well as clinical, forensic and academic laboratories in addition to organizations focused on food safety, clean water and environmental sustainability.
Biotage is headquartered in Uppsala in Sweden and employs over 500 people worldwide. The Group had sales of 1,566 MSEK in 2022 and our products are sold in more than 80 countries. Biotage’s share (BIOT) is listed in the Large Cap segment on the NASDAQ Stockholm.
Copyright © 2023 Biotage