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Biotage^® PS-DEAM

Effective scavenger for a variety of oxophilic organometallic, inorganic complexes, including boronic acids and Lewis acids

PS-DEAM is a polystyrene-bound diethanolamine, which is a resin-bound equivalent of the tridentate (N, O, O) N-alkyldiethanolamine ligand. PS-DEAM is an effective scavenger for a variety of oxophilic organometallic and inorganic complexes. The resin can be used to quench reactions and remove metallic reagents, catalysts or byproducts, allowing the purified product to be isolated by filtration. Boronic acids are scavenged by PS-DEAM. This has been exploited in the purification of Suzuki reactions through the removal of excess boronic acid and coupling byproducts.

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Biotage® PS-DEAM Product Note

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Part numbers

Part No.	Description	Pack Size	List Price
800433	Biotage® PS-DEAM, 1 Kg	1		Add to quote/cart
800430	Biotage® PS-DEAM, 10 g	1	91 USD	Add to quote/cart
800432	Biotage® PS-DEAM, 100 g	1	587 USD	Add to quote/cart
800431	Biotage® PS-DEAM, 25 g	1	189 USD	Add to quote/cart

Specifications

RESIN TYPE 1% Cross-linked poly(styrene-codivinylbenzene)

CHEMICAL NAME polystyrene-bound diethanolamine, (tridentate (N, O, O) N-alkyldiethanolamine ligand)

APPLICATION Scavenging oxophilic metal complexes, including boronic acids, titanium(IV) chloride, titanium(IV) isopropoxide, and tin (IV) chloride

COMPATIBLE SOLVENTS THF (7.5 mL/g), DCM (4.0 mL/g), MeOH (3.0 mL/g), DMF (6.7 m/g). PS-DEAM can also be used in THFEtOH, THF-MeOH mixtures

BULK DENISTY 350g /L

TYPICAL SCAVENGING CONDITIONS 2 – 3 equivalents of PS-DEAM relative to boronic acid at room temperature for 4 h.

STORAGE Cool dry / closed container

SHELF-LIFE / RETEST DATE 5 years / typically annually thereafter depending on process

NOMINAL CAPACITY 1.5-2.0 mmol/g

PARTICLE SIZE 75-150 microns

Biotage® PS-DEAM Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.

Biotage® PS-DEAM Product Note

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Efficiently deliver chemistry

More effective than traditional methods, polymer supported chemistry has been used widely in applications for over fifty years. Biotage supported reagents and scavengers are based on functionalized polystyrene or silica polymers and are 100% insoluble, therefore can be added to reactions and completely removed afterwards.

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Industry Proven

Key supplier to industry for over 15 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable and avoiding the need for problematic work-ups

From grams in research through to multi kilogram quantities in production campaigns. Biotage®

PS-DEAM is effective at removing common Lewis acids, including Ti(IV) and Sn(IV) complexes. PS-DEAM has been found to scavenge titanium(IV) chloride from Sakurai and related reactions.

Titanium(IV) chloride and its alkoxide derivatives are widely used as Lewis acid catalysts in a number of important organic reactions. The work up of these reactions is an aqueous quench, forming a very flocculent white TiO2 precipitate, which can be problematic. The application of PS-DEAM, avoids the need to quench with water, resulting in metal free products, without troublesome work up procedures.

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Fully Documented and Quality Assured

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.

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Biotage^® PS-DEAM

Effective scavenger for a variety of oxophilic organometallic, inorganic complexes, including boronic acids and Lewis acids

Part numbers

Literature

Specifications