Biotage^® PS-Isocyanate

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers.

Biotage® PS-Isocyanate is a polystyrene-bound scavenger, targeting nucleophiles such as amines and alkoxides. Resin-bound scavengers are added after a reaction is complete in order to quench and react selectively with excess reactants and/or reaction by-products. The resulting resin-bound adducts are removed by simple filtration.

PS-Isocyanate is a 1% cross-linked poly(styreneco-divinylbenzene) which has pendent benzylisocyanate functionality. The resin is produced from aminomethyl resin by a superior process which gives high conversion with minimal urea formation as determined by IR spectroscopy. The resin can readily scavenge excess nucleophiles, which are often used to drive reactions to completion. This facilitates workup and purification.1–5 The reaction of nucleophiles with the isocyanate moiety occurs without liberation of small molecule by-products.