Biotage offers a range of products for reaction mixture work-up and preparation of organic extracts.
A complete set of tools to speed up traditional work flow processes and also enhance productivity and flexibility in the laboratory. These products range from solid supported reagents and scavengers, including the market leading Biotage Metal Scavengers, through to laboratory essentials, such as tubes, frits and separators, which can improve even the simplest of procedures.
The offer of work-up products spans over a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.
Catch & Release and Scavenging of Basic Compounds
ISOLUTE® SCX-2 is a silica-based media with a chemically bonded propylsulfonic acid functional group. It is used for the isolation of
a wide range of basic compounds using both catch & release and scavenging protocols. ISOLUTE SCX-2 is available packed into SPE
cartridges for flow-through. Using the catch & release approach, basic target compounds can be isolated from a range of reaction mixtures. ISOLUTE SCX-2 cartridges can be used to remove excess basic reagents, allowing neutral or acidic compounds to pass straight through to the collection vessel.
Catch & Release and Scavenging of Acidic Compounds
ISOLUTE® PE-AX is a silica-based sorbent with a chemically bonded quaternary amine functional group. It is used for the isolation of a wide range of acidic compounds using both catch & release and scavenging protocols. ISOLUTE PE-AX is available packed into SPE cartridges for flow-through. Using the catch &
release approach, acidic target compounds can be isolated from a range of reaction mixtures. ISOLUTE PE-AX cartridges can be
used in a scavenging mode to remove excess acidic reagents, allowing neutral or basic compounds to pass straight through to the collection vessel.
Simultaneous Scavenging of Basic and Acidic Compounds
ISOLUTE® PE-AX/SCX-2 is a silica-based media with chemically bonded propylsulfonic acid and quaternary amine functional groups. It is used for the isolation of a wide range of neutral compounds. ISOLUTE PE-AX/SCX-2 is available packed into SPE cartridges flow-through.
Concentration of Prep-LC Fractions Using Catch & Release
ISOLUTE® 103 is a hydroxylated polystyrene divinylbenzene co-polymer. The resin is used for the isolation of a wide range of compounds from prep LC fractions using catch & release protocol. The approach replaces the need for time-consuming evaporation of aqueous based fractions.
Synthetic organic chemistry is the genesis of new pharmaceutical and commercial chemical products. In short, it is based on the idea that two or more carbon-based compounds can be forced to react using heat, or other energy source, to create a new, novel product – but this we already know.
What are the steps most chemists follow to do this successfully?
The offer of work-up products spans over a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.
ISOLUTE® Phase Separators are used to separate aqueous and chlorinated solvents following liquid-liquid extraction. The proprietary filtration device allows the flow of the organic solvent but holds up the aqueous layer (for up to 24 hours).
Sodium sulfate is commonly used for drying water-immiscible organic solvents. ISOLUTE® Sodium Sulfate Drying Cartridges are a convenient alternative to using the bulk material. The male/female Luer design
allows the cartridge to be placed in-line after the main work-up cartridge. Alternatively, connect to an empty reservoir and load larger volumes of solvent. No need to use additional equipment. Just plug in and filter for instant results. The cartridge contains 2.5 g sodium sulfate and can remove up to 3.5 mL water.
Celite* cartridges are used as a filtration device for removal of “tar” and particulate materials (e.g. catalysts, as first- stage work-up following organic synthesis). The cartridges contain an inert Celite material, a modified diatomaceous earth, with an optimized particle-size distribution for flow-through processing. The cartridge holds up catalysts such as insoluble metal oxides and Pd/C, providing filtrates for subsequent work-up. The retention of the catalyst in a cartridge format minimizes safety issues and cross-contamination, a common problem when the catalyst is captured in an open filtration device such as a sintered funnel.
*Celite is a trademark owned by Johns-Manville Corporation
ISOLUTE® HM-N is a modified form of diatomaceous earth. The support has many uses in reaction work-up, including:
Synthetic organic chemistry is the genesis of new pharmaceutical and commercial chemical products. In short, it is based on the idea that two or more carbon-based compounds can be forced to react using heat, or other energy source, to create a new, novel product – but this we already know.
What are the steps most chemists follow to do this successfully?
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
120-1151-D | 15 mL Frit Inserter | 5 | 67 USD | Add to quote/cart |
120-1151-J | 150 mL Frit Inserter | 1 | 31 USD | Add to quote/cart |
120-1151-E | 25 mL Frit Inserter | 1 | 30 USD | Add to quote/cart |
120-1151-F | 70 mL Frit Inserter | 1 | 30 USD | Add to quote/cart |
122-2100 | Biotage® FlashVac rack special | 1 | Add to quote/cart | |
122-0030 | Biotage® FlashVac silicone lid gasket | 1 | 40 USD | Add to quote/cart |
122-1030 | Biotage® FlashVac-10 19 mm rack | 1 | 284 USD | Add to quote/cart |
122-0049 | Biotage® FlashVac-10 and -20 glass tank | 1 | 328 USD | Add to quote/cart |
122-0044 | Biotage® FlashVac-10 and -20 rack handle | 1 | 23 USD | Add to quote/cart |
122-0047 | Biotage® FlashVac-10 lid | 1 | 1186 USD | Add to quote/cart |
122-1034 | Biotage® FlashVac-10 rack for 25 mm tubes | 1 | 261 USD | Add to quote/cart |
122-1036 | Biotage® FlashVac-10 Top/Mid PLATE, 25 mm | 1 | 113 USD | Add to quote/cart |
122-1019 | Biotage® FlashVac-10 with 19 mm 10 Position rack | 1 | 1645 USD | Add to quote/cart |
122-1025 | Biotage® FlashVac-10, 10 Ports with 25 mm rack | 1 | 1746 USD | Add to quote/cart |
122-2061 | Biotage® FlashVac-20 19 mm rack | 1 | 299 USD | Add to quote/cart |
122-2062 | Biotage® FlashVac-20 25mm rack | 1 | 284 USD | Add to quote/cart |
122-0048 | Biotage® FlashVac-20 lid, complete | 1 | 1186 USD | Add to quote/cart |
122-2019 | Biotage® FlashVac-20 with 19mm 20 position rack | 1 | 1645 USD | Add to quote/cart |
122-2025 | Biotage® FlashVac-20 with 25mm 10 position rack | 1 | 1645 USD | Add to quote/cart |
123-2016 | Biotage® Gravity rack with 16 mm collection tube rack | 1 | 718 USD | Add to quote/cart |
123-2019 | Biotage® Gravity rack with 19 mm collection tube rack | 1 | 718 USD | Add to quote/cart |
123-2119 | Biotage® Gravity Rack, TOP/MID plate, 19 mm | 1 | 119 USD | Add to quote/cart |
810-0100-D | Celite 545 1 g/15 mL | 20 | 119 USD | Add to quote/cart |
810-0100-C | Celite 545 1 g/6 mL | 30 | 143 USD | Add to quote/cart |
810-0100-CG | Celite 545 1 g/6 mL (Tabless) | 30 | 158 USD | Add to quote/cart |
810-1000-J | Celite 545 10 g/150 mL | 8 | 113 USD | Add to quote/cart |
810-0250-E | Celite 545 2.5 g/25 mL | 20 | 149 USD | Add to quote/cart |
810-0045-P01 | Celite 545 45 mg plate | 1 | 203 USD | Add to quote/cart |
120-1110 | Flash Luer Lock to Luer Adapters | 25 | 52 USD | Add to quote/cart |
103-0200-E | ISOLUTE® 103 2 g/25 mL | 20 | 747 USD | Add to quote/cart |
103-0020-BG | ISOLUTE® 103 200 mg/3 mL (Tabless) | 50 | 335 USD | Add to quote/cart |
103-0020-C | ISOLUTE® 103 200 mg/6 mL | 30 | 179 USD | Add to quote/cart |
103-0020-CG | ISOLUTE® 103 200 mg/6 mL (Tabless) | 30 | 195 USD | Add to quote/cart |
103-0500-E | ISOLUTE® 103 5 g/25 mL | 20 | 1798 USD | Add to quote/cart |
103-0050-C | ISOLUTE® 103 500 mg/6 mL | 30 | 344 USD | Add to quote/cart |
103-0050-CG | ISOLUTE® 103 500 mg/6 mL (Tabless) | 30 | 357 USD | Add to quote/cart |
180-0300-P01 | ISOLUTE® 96 Si-Thiol 300 mg plate | 1 | 471 USD | Add to quote/cart |
121-9650 | ISOLUTE® Array 24 | 1 | 208 USD | Add to quote/cart |
121-9660 | ISOLUTE® Array 24 Sealing Caps | 50 | 23 USD | Add to quote/cart |
120-1920-T | ISOLUTE® ARRAY Phase separator loose wells 2 mL | 100 | 149 USD | Add to quote/cart |
120-1920-TP | ISOLUTE® ARRAY PHASE SEPARATOR PLATE 2ML | 1 | 195 USD | Add to quote/cart |
420-5000-J | ISOLUTE® CN 50 g/150 mL | 8 | 1035 USD | Add to quote/cart |
420-7000-J | ISOLUTE® CN 70 g/150 mL | 8 | 1339 USD | Add to quote/cart |
120-1106 | ISOLUTE® Column Adapter 150 mL columns | 5 | 225 USD | Add to quote/cart |
120-1215-D | ISOLUTE® Double Fritted Reservoir (SG), 15 mL 20 µm PE | 100 | 195 USD | Add to quote/cart |
120-1218-J | ISOLUTE® Double Fritted Reservoir (SG), 150 mL 20 µm PE | 25 | 195 USD | Add to quote/cart |
120-1217-F | ISOLUTE® Double Fritted Reservoir (SG), 70 mL 20 µm PE | 50 | 126 USD | Add to quote/cart |
120-1120-K | ISOLUTE® Filtration Column 50 mL | 25 | 208 USD | Add to quote/cart |
456-1000-F | ISOLUTE® FLASH SCX-2 10 g/70 mL | 16 | 475 USD | Add to quote/cart |
456-0100-C | ISOLUTE® FLASH SCX-2 1g/6ml | 30 | 188 USD | Add to quote/cart |
456-0200-D | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 188 USD | Add to quote/cart |
456-0200-DG | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 225 USD | Add to quote/cart |
456-2000-F | ISOLUTE® FLASH SCX-2 20 g/70 mL | 16 | 941 USD | Add to quote/cart |
456-2500-J | ISOLUTE® FLASH SCX-2 25 g/150 mL | 8 | 576 USD | Add to quote/cart |
456-0500-E | ISOLUTE® FLASH SCX-2 5 g/25 mL | 20 | 335 USD | Add to quote/cart |
456-5000-J | ISOLUTE® FLASH SCX-2 50 g/150 mL | 8 | 1135 USD | Add to quote/cart |
456-0050-B | ISOLUTE® FLASH SCX-2 500 mg/3 mL | 50 | 208 USD | Add to quote/cart |
456-7000-J | ISOLUTE® FLASH SCX-2 70 g/150 mL | 8 | 1581 USD | Add to quote/cart |
120-1365-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 10 µm PE | 100 | 179 USD | Add to quote/cart |
120-1385-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 10 µm PTFE | 100 | 281 USD | Add to quote/cart |
120-1115-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 20 µm PE | 100 | 172 USD | Add to quote/cart |
120-1375-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 20 µm PTFE | 100 | 315 USD | Add to quote/cart |
120-1369-J | ISOLUTE® Fritted Reservoir (SG), 150 mL 10 µm PE | 25 | 248 USD | Add to quote/cart |
120-1119-J | ISOLUTE® Fritted Reservoir (SG), 150 mL 20 µm PE | 25 | 195 USD | Add to quote/cart |
120-1366-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 10 µm PE | 100 | 248 USD | Add to quote/cart |
120-1386-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 10 µm PTFE | 100 | Add to quote/cart | |
120-1116-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 20 µm PE | 100 | 208 USD | Add to quote/cart |
120-1376-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 20 µm PTFE | 100 | 412 USD | Add to quote/cart |
120-1396-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 5 µm PTFE | 100 | 418 USD | Add to quote/cart |
120-1367-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 10 µm PE | 50 | 149 USD | Add to quote/cart |
120-1387-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 10 µm PTFE | 50 | 268 USD | Add to quote/cart |
120-1118-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 20 µm PE | 50 | 126 USD | Add to quote/cart |
120-1377-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 20 µm PTFE | 50 | 344 USD | Add to quote/cart |
120-1397-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 5 µm PTFE | 50 | 316 USD | Add to quote/cart |
801-1000-J | ISOLUTE® MgS04 10 g/150 mL | 8 | 110 USD | Add to quote/cart |
802-0250-D | ISOLUTE® NA2S04 2.5g/15 mL | 20 | 143 USD | Add to quote/cart |
503-1000-F | ISOLUTE® PE-AX 10 g/ 70 mL | 16 | 550 USD | Add to quote/cart |
503-0200-D | ISOLUTE® PE-AX 2 g/15 mL | 20 | 215 USD | Add to quote/cart |
503-2000-F | ISOLUTE® PE-AX 20 g/ 70 mL | 16 | 1105 USD | Add to quote/cart |
503-0500-E | ISOLUTE® PE-AX 5 g/25 mL | 20 | 335 USD | Add to quote/cart |
988-1000-F | ISOLUTE® PE-AX/SCX-2 10 /70 mL | 16 | 955 USD | Add to quote/cart |
988-2000-F | ISOLUTE® PE-AX/SCX-2 20 g/70 mL | 16 | 1845 USD | Add to quote/cart |
988-0500-E | ISOLUTE® PE-AX/SCX-2 5 g/25 mL | 20 | 619 USD | Add to quote/cart |
120-1906-D | ISOLUTE® Phase separator 15 mL | 100 | 240 USD | Add to quote/cart |
120-1909-J | ISOLUTE® Phase separator 150 mL | 25 | 254 USD | Add to quote/cart |
120-1903-B | ISOLUTE® Phase separator 3 mL | 100 | 195 USD | Add to quote/cart |
120-1903-BG | ISOLUTE® Phase separator 3 mL tabless | 100 | 203 USD | Add to quote/cart |
120-1905-CG | ISOLUTE® Phase separator 6 mL tabless | 100 | 261 USD | Add to quote/cart |
120-1907-E | ISOLUTE® Phase separator column 25 mL | 100 | 315 USD | Add to quote/cart |
120-1905-C | ISOLUTE® Phase separator column 6 mL | 100 | 240 USD | Add to quote/cart |
120-1910-P05 | ISOLUTE® Phase separator plate, fixed well | 5 | 470 USD | Add to quote/cart |
120-1910-P01 | ISOLUTE® PHASE SEPARATOR PLATE,FIXED WELL | 1 | 113 USD | Add to quote/cart |
120-1901-A | ISOLUTE® Phase separator, 1 mL | 100 | 164 USD | Add to quote/cart |
120-1908-F | ISOLUTE® Phase separator, 70 mL | 50 | 203 USD | Add to quote/cart |
120-1106-D | ISOLUTE® Reservoir (SG) 15 mL | 100 | 97 USD | Add to quote/cart |
120-1110-J | ISOLUTE® Reservoir (SG) 150 mL | 25 | 126 USD | Add to quote/cart |
120-1107-E | ISOLUTE® Reservoir (SG) 25 mL | 100 | 119 USD | Add to quote/cart |
120-1109-F | ISOLUTE® Reservoir (SG) 70 mL | 50 | 83 USD | Add to quote/cart |
532-1000-F | ISOLUTE® SCX-2 10 g/70 mL | 16 | 524 USD | Add to quote/cart |
532-0200-D | ISOLUTE® SCX-2 2 g/15 mL | 20 | 203 USD | Add to quote/cart |
FlashVac Sample Processing Manifolds are used to process the complete range of ISOLUTE work-up columns. The manifolds can be used for Catch & Release and scavenging SPE, filtration, and off-line sample loading prior to flash chromatography.
Biotage offers a range of accessories for use with filtration, Catch & Release, and scavenging SPE columns in organic synthesis work-up schemes.
Accessories include stop-cocks, luer tip caps, cartridge adaptors.
Biotage is a global supplier and solutions partner to a wide range of customers within drug discovery and development and analytical testing. With strong expertise in separation and purification technologies, and a focus on leveraging intelligent workflow solutions, we aim to efficiently support the advancement and protection of human health.
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