Optimized sample preparation for low level determination of alcohol marker EtG from hair

Hair analysis is growing in popularity due to the non-invasive nature of the sample collection. Hair testing can also provide advantages over other more widely used matrices, such as determination of prolonged exposure and potential timelines. However, as a solid matrix, sample preparation can often be lengthy and labor intensive. Minor ethanol metabolites such as ethyl glucuronide (EtG) and ethyl palmitate (EtPa) can be measured in hair as direct markers of alcohol consumption. As suggested by the Society of Hair Testing (SoHT) in 2019, EtG determination from hair is the preferred marker for the assessment of abstinence. This poster aims to demonstrate improved workflow and clean-up of hair matrix to allow low level EtG determination required for alcohol abstinence testing.

Literature number: P260