Sample preparation for the determination of an extended PFAS panel from human serum

PFAS targets are of concern because of their high persistence, bioaccumulation and slow elimination with potential impacts on human and environmental health. Recently, human exposure has been linked with changes in metabolism, increased cholesterol, and high incidence of some forms of cancer. This poster presents a novel method for the simultaneous determination of long and short chain PFAS in human serum at clinically relevant levels. ISOLUTE® PLD+ for PFAS, due to its optimised sorbent chemistry and functionality, allows a simple solvent crash/filtration-based workflow. With subtle modification to allow suitable extraction of challenging longer chain PFAS targets we have developed a robust, high-sensitivity method for the clean-up of 36 PFAS compounds from human serum.

Literature number: P276