ISOLUTE® Si Propylsulfonic Acid (SCX-2) metal scavenger/scavenger

By Biotage

ISOLUTE® Si-Propylsulfonic acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. SCX-2 is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/ base product binding interactions with the scavenger. If the product is basic then Si-Tiol, SI TMT, MP-TMT or Si-Trisamine may be utilized instead. Other uses in chemistry include (a) scavenge (removing) amines and other bases from solution (b) as an acid catalyst in reactions or (c) catch and release purification of amines, to facilitate either solvent switching or amine purification. The advantage of using SCX-2 as a polymer supported acid is that it eliminates traditional laborious work-up steps.

Literature number: PPS373

Published: Dec 6, 2025 9:43:17 PM

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