Biotage® PS-Triphenylphosphine solid-supported phosphine

Biotage® PS-Triphenylphosphine is a diphenylphosphinated polystyrene resin that is a solid-supported equivalent of triphenylphosphine. The capacity of the resin is determined by the quantitation of benzyl bromide uptake in DMF (GC, internal standard method). The resin can readily convert alcohols or carboxylic acids to the corresponding chlorides or acid chlorides in carbon tetrachloride (Scheme 1).1–3 Reaction conditions are relatively mild and the products are formed in high yield and purity.

Literature number: PPS389