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Why silica column selection matters: A performance comparison of three flash column brands

Small molecules and synthetic therapeutics Technical note

There are many companies manufacturing flash columns and media. By and large, a column from any of the manufacturers will likely perform a purification with the right method – but how well?

The silica used to pack flash columns varies in its performance, sometimes dramatically, due to differences in surface area, porosity, purity, consistency, etc. Therefore, it is important to use columns from a reliable source with consistent performance and selectivity.

In this technical note, a Biotage® Sfär HC silica column is compared to two other popular brands with similar media, one from Competitor G and another from Competitor P, using two different samples - a reaction mixture and a lipid mixture. 

Literature number: PPS708

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