Literature

Overview This white paper evaluates Biotage reversed-phase solid-phase extraction (SPE) sorbents for peptide desalting prior to LC-MS/MS analysis. Across recovery, reproducibility, retention, and samp...

Introduction Preparative purification of synthetic peptides is commonly performed using reversed-phase chromatography, with analytical HPLC routinely used to assess crude purity and establish retentio...

The Pentelute Lab at MIT uses Biotage® Selekt flash chromatography to rapidly purify synthetic peptides, accelerate hit discovery and move research forward with less time spent on purification.

Dr Diego Núñez Villanueva is a Tenured Scientist at the Institute of Medicinal Chemistry of the Spanish National Research Council (IQM‑CSIC). Prior to this, he spent several years in the UK, working a...

In peptide purification, mobile-phase acidity (available solution protons) strongly influences peptide charge-state distribution, retention, and separation selectivity. Trifluoroacetic acid (TFA) is w...

Introduction Flash chromatography remains a cornerstone purification technique across pharmaceutical, academic, and industrial chemistry workflows due to its speed, scalability, and robustness.1 Perfo...

Introduction Large numbers of related peptides are often required for many types of research, for example in proteomic studies of post-translational modifications. While this sometimes can be achieved...

Introduction The UV absorption spectrum of some solvents overlaps with the product they dissolve, meaning that fraction collection processes cannot distinguish between solvent and product. Luckily, th...

This application shows how the β-amyloid (1-42) peptide was successfully synthesized in 0.1 mmol scale on a Biotage® Initiator+ Alstra™ fully automated microwave peptide synthesizer.