Literature

Antimicrobial peptides (AMPs) are evolutionarily conserved peptide sequences often found in plants, animals, and humans. They play a significant role in the host’s innate immune response by acting as ...

Summary This application note highlights how simple Gradient Optimization and single vessel product collection – enabled by a collection bed bypass function - minimized solvent use and reduced the num...

Introduction The interest in naturally occurring and designed bioactive cyclic peptides is ever increasing.1–4 Cyclic peptides often have an increased stability against proteolysis compared with linea...

Introduction Reductive amination is a favored chemical reaction in synthesis of organic amines. However, like many synthetic techniques, it can create side reactions and byproducts that require remova...

COVID-19 triggered accelerated research into vaccine development. Some of the vaccines are based on mRNA which, if not protected, easily degrades in humans before its therapeutic benefits can be reali...

This application note demonstrates a variable scale synthesis on the Biotage® Initiator+ Alstra™ using the ACP (65–74) fragment as a model peptide.

This application note describes optimization for a fully automated synthesis and on-resin cyclization of oxytocin enabled by Branches™ , a unique software feature of the Biotage® Initiator+ Alstra™ pe...

Peptides have returned to the forefront of drug discovery efforts as unbiased screening technologies have improved and the rules defining passive cell permeability have been clarified. As a result, th...

Just like a compass guides you north, Biotage® Selekt Kompass keeps your chromatography on the right path. In regulated environments, precision matters, and Biotage® Selekt Kompass ensures every site ...

Peptides have returned to the forefront of drug discovery efforts as unbiased screening technologies have improved and the rules defining passive cell permeability have been clarified. As a result, th...