Voriconazole is a triazole-based antifungal drug that is widely used to treat fungal infections. However, because severe side effects are known, it is included in Therapeutic Drug Monitoring (TDM) regimes. Especially for patients with severe or refractory fungal infections or hematopoietic stem cell transplantation, blood concentrations are measured for specific drug treatments.
This method is designed to provide a LC-MS/MS analytical alternative to the commonly used UV based end point, for measurement of this antifungal drug.
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