BIOMARK002.183 - Scaling up with Metal Scavengers Social

ISOLUTE^® SCX-2

Powerful metal scavenger with affinity for alkali metals

ISOLUTE® SCX-2 belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. Since SCX-2 is acidic in nature, it is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/base product binding interactions with the scavenger.

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ISOLUTE® SCX-2 Product Note

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Part numbers

Part No.	Description	Pack Size	List Price
9536-1000	ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 1 kg	1	3002 USD	Add to quote/cart
9536-0010	ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 10 g	1	78 USD	Add to quote/cart
9536-0100	ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 100 g	1	326 USD	Add to quote/cart
9536-0025	ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 25 g	1	143 USD	Add to quote/cart
9536-0500	ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 500 g	1	1700 USD	Add to quote/cart
K-MS-3	Metal Scavenging Screening Kit - SPE	1	179 USD	Add to quote/cart
K-MS-2	Metal Scavenging Toolkit - Batch	1	471 USD	Add to quote/cart

Literature

PRODUCT NOTE

ISOLUTE^® SCX-2 Product Note

Key facts and figures and quick at a glance usage data

APPLICATION NOTE

Metal Scavengers and ICH Q3D, A Regulatory Perspective

This note highlights key issues and perspectives relating to the successful use of metal scavengers in pharma, under ICH Q3D

POSTER

New Applications of Ruthenium Scavenging

Next to palladium, ruthenium is the next most frequently used metal. It is much more difficult to remove from reactions. This poster highlights methods and approaches towards ruthenium mitigation.

POSTER

Metal Scavengers in Process Chemistry

This poster highlights advantages and helps to identify potential pitfalls associated with the application of metal scavengers in scale up and process SOPs.

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Specifications

CHEMICAL NAME Silica Propylsulfonic Acid (Si-propylsulfonic acid; SCX-2)

RESIN TYPE Bioanalytical grade silica

APPLICATION Scavenger of amine, Catch-and-Release, Acid catalyst

TYPICAL SCAVENGING CONDITIONS Stir crude reaction mixture with 2–4 equivalents for 1 h and filter

COMPATIBLE SOLVENTS Methanol (MeOH), Dichloromethane (DCM), Acetonitrile (MeCN), Acetone, Ethyl Acetate (EtOAc), N,N-Dimethylformamide (DMF), Dimethylsulfoxide (DMSO)

STORAGE Cool, dry location

SHELF-LIFE / RETEST DATE 5 years / typically annually thereafter depending on process

CAPACITY 0.7 mmol/g

PARTICLE SIZE 40-60 microns

BULK DENSITY 700g /L

ISOLUTE® SCX-2 Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in metal scavenging and is the number 1 choice for processes worldwide. Clean, effective, simple and specific metal scavengers allow you to remove metal impurities whilst maximizing product recovery.

ISOLUTE® SCX-2 Product Note

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Powerful metal scavenging

More effective than traditional methods, less energy intensive than distillation, less API loss compared to carbon, less time and risk of failed batches than recrystallization, operationally simple and designed for plug and play approaches, in fixed beds or batch stirring applications.

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Industry Proven

Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable

From grams in research through to multi kilogram quantities in production campaigns

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Fully Documented and Quality Assured

Lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement

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ISOLUTE^® SCX-2

Powerful metal scavenger with affinity for alkali metals

Part numbers

Literature

Related Videos

Quick Introduction to Metal Scavenging

Specifications