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Automate high-throughput parallel peptide purification

High-throughput peptide synthesis is essential for early-stage drug discovery, but purification often creates bottlenecks. Traditional RP-HPLC methods are slow and solvent-intensive. Automated, plate-based parallel purification offers a faster, more sustainable alternative:

Achieve high peptide purity with simple, pre-optimized protocols
Purify up to 96 peptides in parallel for increased throughout
Cut solvent use for a more environmentally friendly workflow
Lower costs by improving efficiency and productivity

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Two solutions, one goal

Biotage offers two automated, plate-based solutions to streamline peptide purification after synthesis.

Biotage® PeptiRen-96: A versatile solution for all peptide types, using reversed-phase C18 media for solid-phase extraction (SPE) to achieve over 60% average purity, making it ideal for preliminary screening.
Biotage® PeptiPEC-96: Optimized for synthetic peptides with a free N-terminus, delivering over 80% average purity and improving validation assays and structure-activity relationship (SAR) studies.

Compare the solutions

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Novel methodology for pure peptides

Biotage® PeptiPEC-96 parallel peptide purification employs a catch-and-release methodology based on the PurePep® EasyClean (PEC™) technology from Gyros Protein Technologies.

Learn more

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Parallel peptide workflows for streamlined library delivery

This white paper outlines a parallel peptide workflow using Syro parallel peptide synthesizers and Biotage® PeptiRen-96 plates with optimized solid-phase extraction protocols, enhancing library purity and eliminating labor-intensive ether precipitation. Together, these tools enable an efficient peptide library discovery program.

Read the white paper

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Optimizing peptide library purification: data-driven insights

Interest in large synthetic peptide libraries is growing, requiring workflow changes to prevent bottlenecks. This webinar presents data on parallel peptide purification, replacing manual steps while preserving integrity, yield, and potentially improving purity.

Watch the webinar

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Solid-phase extraction media comparison for synthetic peptide clean-up

Automating solid-phase extraction (SPE) in a 96-well plate format allows high-throughput peptide synthesis and parallel sample processing. However, selecting the right media that interacts predictably with peptides is key to achieving optimal results. This application note compares the performance of Biotage® PeptiRen C18 media with other commercially available options.

Read the application note

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Parallel purification of 192 peptides in plate-based format

This application note demonstrates the use of Biotage® PeptiPEC-96 High-Throughput Kits and the Biotage® Extrahera™-Peptide workstation for the automated purification of a peptide library containing 192 SARS-CoV-2 epitopes, designed for use in T-cell response assays.

Read the application note

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Related products

Biotage® Extrahera™ Classic | Multi-format sample prep workstation

An automated workstation for sample prep processing in plates and cartridges and parallel peptide purification.

Biotage® PeptiRen and Biotage® PeptiPEC | Peptide purification plates

High-throughput, automated parallel peptide purification solutions. Low solvent use and faster processing, enhancing screening and discovery.