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Higher performance flash columns are becoming all the rage these days. Chemists are using them for challenging as well as for routine purification. As a result, I am often asked, "do I need high-perfo...

An interesting question, at least to me. Depending on the detector brand, some mass spectrometer manufacturers recommend acetonitrile while others recommend methanol. Is there a real difference betwee...

As synthetic chemistry has evolved, so has flash chromatography. Target molecule synthesis is becoming more complicated and the synthetic products more polar. This shift in compound polarity has chang...

Acetone, as you know, is a terrific solvent. It dissolves many organic molecules, evaporates easily, is both water and organic soluble, and is cheap (relatively). These attributes tell me it should be...

I have previously posted on the topic of normal-phase optimization by evaluating different solvent blends or mixtures. I have also touched on reversed-phase method development as well suggesting chemi...

In previous posts I have discussed some options and techniques to improve detection of poorly absorbing or UV-transparent compounds – by wavelength focusing and by evaporative light-scattering (ELS).

Over the past several years, automated flash chromatography has evolved to include in-line mass detection. Typically, these single-quadrupole mass detectors are outfitted with either an atmospheric pr...

APCI (atmospheric pressure chemical ionization) and ESI (electrospray ionization) are the two most frequently utilized mass detection tools for automated flash chromatography.

Biotage, pioneers in flash chromatography, started packing columns with silica for flash purification 30 than years ago. Site director Chris Williams tells the story of packing columns - "part science...

This is an interesting question that does not have a straightforward answer. In fact, there are many materials that are potentially useful sorbents for dry loading crude mixtures. Some of the more pop...