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Small Molecules and Synthetic Therapeutics

Solid phase extraction is emerging as a strategy for peptide library clean up in parallel. While reversed phase is a robust media choice, ...

Small Molecules and Synthetic Therapeutics

ELSD is useful for finding molecules that have no chromophore during flash purification. Here we show how signal intensity can vary between ...

Small Molecules and Synthetic Therapeutics

This post describes how ELSD make-up solvent choice can impact detected peak sensitivity.

Small Molecules and Synthetic Therapeutics

This post highlights the benefits achievable when using both UV and ELS detection.

Small Molecules and Synthetic Therapeutics

This post shows an example of a reaction mix purification requiring ELS detection.

Small Molecules and Synthetic Therapeutics

DIC/Oxyma coupling conditions are thought to be acidic enough to prematurely cleave peptide from chloro-trityl resins. Here we show how ...

Small Molecules and Synthetic Therapeutics

This post highlights the benefits provided by various dry load media.

Small Molecules and Synthetic Therapeutics

This is a troubleshooting post discussing the causes and remedies for wavy chromatographic traces.

Small Molecules and Synthetic Therapeutics

This post describes how organic solvent choice impacts reversed phase separations.

Small Molecules and Synthetic Therapeutics

This post discusses two situations when the addition of a third solvent in a purification method addresses the issue.