How does an acid pH modifier impact flash chromatography?
This post discusses the pros and cons of adding acid to a flash purification method.
How can I overcome chromatography solvent detection interferences
This post discusses the benefits of UV baseline correction with flash chromatography.
Does decreased resin loading improve head-to-tail cyclization?
Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how resin loading can affect purity and challenges associated ...
How much methanol can I use with my silica flash column?
This post examines the true reason silica particles are often found if flash chromatography fractions.
The benefits of UV transparent chromatography solvents
This post discusses the benefits of using UV transparent solvents for flash chromatography to improve compound detectability.
When should amine-bonded columns be used for purification?
This post highlights the ability of amine-bonded flash columns to alter selectivity of neutral compounds to improve their purification.
What are good alternatives to shallow DCM/MeOH gradients?
This post discusses two safer, environmentally friendly purification options to replace DCM - MeOH.
How to effectively use your flash system's diode-array detector
This post highlights how a diode-array UV detector can provide important information about the purity of a collected fraction.
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