Literature
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Choosing the solid-phase extraction media for synthetic peptide clean-up
Summary Solid phase extraction (SPE) is a commonly used method to clean up various types of samples before analyzing them using LCMS. It is also an effective way to improve the purity of crude synthet...
Extraction and analysis methods for fentanyl and fentanyl analogues in whole blood and urine
Introduction Fentanyl and fentanyl-related analogues have been identified as the root cause of several notable drug overdoses in recent years. The demand for testing of these drugs has rapidly increas...
Reducing evaporative crosstalk in urine assays using 96-well plates
LC-MS/MS analysis of volatile analytes is problematic when 96-well plates are used. Solid phase extraction of urine with high drug concentrations can cause contamination of the elution solvent during ...
Evaluation of novel automated sample preparation compared to manual processing in forensic toxicology
Data reliability in forensic toxicology is of paramount importance. The possibility of false positives and/or false negatives can have wide ranging consequences and impacts decisions on various parts ...
Organophosphorous pesticides using automated SPE according to EPA method 8141B
Scope This application note will outline appropriate methods for the extraction of organophosphorus pesticides from ground water as outlined in EPA method 8141B using the Atlantic® C18 SPE disk proces...
Evaluation of on-resin head-to-tail cyclization protocols of peptides using automated peptide synthesizers
Peptide drug discovery programs have advanced to the clinic as the rules for small molecule-like transport and bioavailability have become more thoroughly understood. Macrocyclic peptides, in particul...
Biotage® Extrahera™ GLP software and 21 CFR part 11 regulations
The Biotage® Extrahera™ GLP Software is designed to automate sample preparation in many applications that utilize solid-phase extraction (SPE), supported liquid extraction (SLE), dual mode extraction ...