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Recommended procedures for the preparation of PFAS compounds according to DIN 38407-42
This technical note provides two detailed procedures for preparing PFAS compounds according to DIN 38407-42, one for for 250 mL samples using 500 mg bed mass and one for 50 mL samples using 60 mg bed ...
Determination of monocrotophos, diazinon, malathion, EPN, and methamidaphos from aqueous samples
This application note outlines the extraction of five organophosphate compounds monocrotophos, diazinon, malathion, EPN, and methamidophos using one solid phase extraction method with one pre-treatmen...
Alternatives to DCM/MeOH in normal-phase flash chromatography
Introduction Flash chromatography using elution gradients of dichloro- methane and methanol (DCM/MeOH) are the go-to purification technique for chemists trying to purify polar compound mixtures. Howev...
Using focused gradients to improve peptide purity using reversed-phase flash chromatography
Summary Purification of synthetic peptides represents the largest bottleneck of the entire peptide workflow. Reversed-phase flash chromatography is gaining traction as a strategy to reduce this bottle...
Extraction of amphetamine and designer amphetamine analogues from whole blood using ISOLUTE® SLE+
Figure 1. Structure of Amphetamine and Ethylone Introduction This application note describes the extraction of a range of amphetamine-type compounds from whole blood, prior to GC/MS analysis. A protoc...
Sample preparation method for determination of voriconazole in plasma using ISOLUTE® SLE+
Figure 1. Molecular Structure of Voriconazole. Introduction Voriconazole (Figure 1) is a triazole-based antifungal drug that is widely used to treat fungal infections, including invasive aspergillosis...
Determining PAHs in sea water using automated SPE
Application Note Scope This application note will outline optimized methods for the extraction of polycyclic aromatic hydrocarbons from sea water using the Atlantic® HLB solid phase extraction disk pr...
How important is flow rate in flash chromatography?
Chemists often wonder about the influence of flow rate on their flash chromatography. Typically, the questions are: If I slow the flow rate will my separation improve? If I speed the flow rate will my...
Developing a scalable metals removal process
This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model Active Pharmaceutical Ingredient (API).