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Catecholamine metabolites vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) are biomarkers for neuroblastoma and catecholamine secreting tumours. We present ...
Urine is a very useful matrix in forensic laboratories, because it is easy to collect and can help determine if a drug has been used recently. There are many viable sample preparation options for urin...
Compliance with GMP is a necessary condition for drug authorization however the scrutiny that it demands can pose local engineering and chemistry issues because process chemists are under increasing p...
Oral fluid represents a complex, heterogeneous biological fluid primarily produced by the parotid, submandibular, and sublingual salivary glands. Together, these glands make the majority of saliva, wh...
Breast feeding is beneficial in meeting the nutritional and immunological needs of infants. Using illegal drugs while breast feeding can have severe consequences for both infant and mother. At Biotage...
Introduction Taking chemistry from the bench to the market efficiently requires optimized synthetic and purification routes. Choosing the right reaction solvent and purification method will help achie...
The screening for elevated levels of methylmalonic acid (MMA) in serum is commonly used as a clinical diagnostic indicator of Cobalamin (Vitamin B12) deficiency in humans. MMA is commonly analyzed usi...
Introduction The Biotage PhyTip® columns are the proven technology of choice for the purification of recombinant proteins and antibodies when requiring robust high quality reproducible separations fro...
In the forensic world, many cases are decided based on the laboratory test results. Yet, while forensic testing is critically important for legal demands, many labs remain constrained by tight budgets...
Utilization of synthetic chemistry routes developed in late lead optimization is becoming more widespread as the desire to efficiently confirm pre-clinical compounds has increased. In some cases, chem...