Enhancing solid-phase peptide synthesis with green chemistry principles

Antimicrobial peptides (AMPs) are evolutionarily conserved peptide sequences often found in plants, animals, and humans. They play a significant role in the host’s innate immune response by acting as a first line of defence against invading pathogenic microbes and have a broad spectrum of antimicrobial activity. AMPs target microbial components that facilitate immune response. They are a key focus in the development of novel antibacterial agents due to their rapid pathogen killing ability and alternative mechanism of action, which make it challenging for pathogens to develop antibiotic resistance.

This study demonstrates that 7:3 BtOAc:DMSO with 20% pip is a promising alternative to DMF, achieving only a 23.72% average purity reduction while reducing solvent consumption by more than two-fold. 

Literature number: P274