Orthogonal flash chromatography reduces organic solvent use while maximizing workflow

In medicinal chemistry each intermediate and final product needs purification. Historically, the primary tool for reaction purification has been normal-phase flash chromatography sometimes followed by reversed-phase preparative HPLC to provide higher purity when needed. While this process works, it can consume large quantities of
organic solvent and slow down the synthesis workflow. 

In this poster we describe an orthogonal flash chromatography approach that uses a small silica normal-phase column at high sample load to provide a crude sample clean-up followed by a high load, small column, reversed-phase flash chromatography step to purify the synthetic product while minimizing solvent use. 

Literature number: P237