Literature

Utilization of synthetic chemistry routes developed in late lead optimization is becoming more widespread as the desire to efficiently confirm pre-clinical compounds has increased. In some cases, chem...

We combine a robust, reliable UV (Visible/Ultraviolet absorbance detector) monitor with a specialized wireless tablet optimized for use in sensitive environments. The Biotage UV Monitor kit features t...

Biotage® PS-Triphenylphosphine is a diphenylphosphinated polystyrene resin that is a solid-supported equivalent of triphenylphosphine. The capacity of the resin is determined by the quantitation of be...

ISOLUTE® Si-Propylsulfonic acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which...

Biotage® PS-TBD is a polymer-supported base, which consists of a bicyclic guanidine moiety (1,5,7-triazabicyclo[4.4.0]dec-5-ene) anchored on polystyrene. Published applications of PS-TBD include alkyl...

Biotage metal scavengers are clean, simple and effective. They help to reduce metal contamination by selectively removing metals from APIs and other pharma compounds. Their ease of application helps r...

Biotage® MP-TMT is a macroporous polystyrene-boundtrimercaptotriazine, a resin-bound equivalent of 2,4,6-trimercaptotriazine(TMT). The resin is designed to scavenge residual palladium from products de...

MP-TsOH resin is a sulfonated macroporous polystyrene resin that is a resin-bound equivalent of p-toluenesulfonic acid (TsOH). The resin may be used as an equivalent to the strong cation-exchange resi...

ISOLUTE® Si-Trisamine is a silica bound equivalent of a trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanate...

Introduction This study was conducted in 3 parts.