Showing posts written by Bob Bickler
Flash chromatography is a purification technique that, by its name, is designed to be fast. Faster than open column chromatography and faster than prep HPLC. Flash chromatography is faster due to the ...
An interesting question for synthesis chemists as the need for reversed-phase flash chromatography for both intermediates and final compounds increases. Historically, normal-phase flash chromatography...
For many chemists, one flash chromatography column is the same as another and only price is considered. This is true for both silica and reversed-phase (C18). However, since there are differences betw...
Flash chromatography is an integral part of the organic synthesis workflow. For most chemists, they make a compound once and then move on to the next synthesis. Sometimes, the synthesis needs to be sc...
Flash chromatography is nearly ubiquitous within organic and medicinal chemistry labs. Most chemists, when the need arises to purify a reaction mixture, will use a silica column (aka normal-phase) for...
Synthesis workflow is the journey taken by chemists when creating a molecule. This journey can be like taking the interstate with no traffic lights and higher speed limits but usually this trip is mor...
While polar compound purification is frequently performed using a silica column and a DCM/MeOH solvent system, there is a need to reduce its use in chromatography for a number of reasons. First, dichl...
For most organic reaction mixture purifications the process is fairly straightforward. Use hexane/ethyl acetate or, for polar compounds, DCM/MeOH. But what do you do if this doesn't work and your comp...
One of the more challenging purifications is that of water-soluble, ionizable compounds. Typically, normal-phase with silica is not used because of the probable non-reversible interactions, especially...
I have recently posted on how solvent choice influences the separation of hard to resolve compounds using normal-phase flash chromatography. As a chemist with an inquiring mind, I thought I would expa...