Showing posts written by Bob Bickler
Our clientele at Biotage have interesting and diverse backgrounds from highly skilled synthetic chemists, to experts in natural product chemistry, to those who are just beginning they journey with che...
Choosing a good purification strategy is an important for successful crude compound purification. A major factor in your strategy is choosing between normal-phase or reversed-phase chromatography. How...
If you synthesize organic amine compounds, especially heterocyclic, secondary, or tertiary amines, you likely have encountered problems with their chromatography using silica columns. With the amine g...
Cannabinoids, naturally occurring compounds found mainly in cannabis and hemp, have seen significant research as potential new therapeutics during the past four to five years with the passing of the 2...
TLC is the tool most used for normal-phase flash chromatography method development. For many chemists, a solvent system of hexane (or heptane) + ethyl acetate is the first, and sometimes only, solvent...
In recent years, most of the interest in the medicinal cannabis market has been focused on CBD (THC-free) and, to a lesser extent, THC. However, the market needs are changing with increasing interest ...
Cannabichromene (CBC) is one of the four most prevalent cannabinoids expressed by cannabis plants (Pollastro, 2018). Unlike the psychoactive tetrahydrocannabinol, CBC is benign in this regard, but doe...
The answer to this question is yes, reversed-phase can sometimes provide a better separation and thus better purification than normal-phase. When is reversed-phase likely to be the better choice is a ...
In many of my previous posts I have used the term column volume, typically abbreviated as CV, as a value used to help determine separation quality and loading capacity. However, I recently was asked a...
Cannabis entrepreneurs continually seek to differentiate themselves from others in the market. Some focus on THC while others focus on CBD.