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Small Molecules and Synthetic Therapeutics

This post helps guide the reader to choose either reversed-phase or normal-phase based on mixture solubility.

Small Molecules and Synthetic Therapeutics

This post provides 5 tips on extending reversed-phase flash chromatography cartridge life.

Small Molecules and Synthetic Therapeutics

This post discusses the principles behind evaporative light-scattering detection (ELSD).

Small Molecules and Synthetic Therapeutics

This post talks about ways to increase sample load.

Small Molecules and Synthetic Therapeutics

This post shows how highly polar compounds can be retained and separated with using expensive "aqueous" reversed-phase columns.

Small Molecules and Synthetic Therapeutics

So, which detector should I use for flash column chromatography?

Small Molecules and Synthetic Therapeutics

Can flash column chromatography be green?

Small Molecules and Synthetic Therapeutics

This post discusses the impact that different sample solvents have on reversed-phase flash chromatography.

Small Molecules and Synthetic Therapeutics

This post answers the question - Does methanol really dissolve silica during flash column chromatography?

Small Molecules and Synthetic Therapeutics

Benefits of acetonitrile over methanol in normal-phase flash column chromatography.