Showing posts written by Biotage
Introduction Discovering new chemical entities (NCEs) or new molecular entities (NMEs) is costly and time consuming. One needs only to look at the top 15 global pharmaceutical companies to see how exp...
Introduction As environmentally responsible chemists we all want to reduce the chemical waste volume we generate in our daily research activities. While the chemicals we use are necessary for what we ...
Figure 1. Structure of Acrylamide. Introduction Acrylamide is a small polar highly water soluble molecule formed when carbohydrate rich foodstuffs are cooked at high temperatures. Acrylamide was first...
Chemical synthesis has been around for a long time - Hermann Kolbe first used the term ‘synthesis’ in the way in which modern chemists understand it in the 19th century1. Many of the important named r...
Introduction The diverse nature of the samples in food safety testing applications adds complexity making method standardisation challenging. However, default methodology for solid matrix pesticide an...
Introduction ISOLUTE® EPH SPE cartridges and associated methodologies have been optimized to efficiently fractionate EPHs into aliphatic and polycyclic aromatic (PAH) fractions (C8–C40 aliphatics, C10...
Summary A novel feature that inserts an isocratic hold into a linear gradient when a compound elutes can improve the separation of partially co-eluting compounds, simplifying flash chromatography meth...
Catecholamine metabolites vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) are biomarkers for neuroblastoma and catecholamine secreting tumours. We present ...
Urine is a very useful matrix in forensic laboratories, because it is easy to collect and can help determine if a drug has been used recently. There are many viable sample preparation options for urin...
Compliance with GMP is a necessary condition for drug authorization however the scrutiny that it demands can pose local engineering and chemistry issues because process chemists are under increasing p...