Sample cleanup approach for the analysis of a multi-class DoA panel in breast milk
By Biotage
Breastfeeding offers significant health benefits for both infants and mothers, promoting optimal nutrition, immune protection, and developmental outcomes. However, maternal use of illicit drugs or misuse of prescription medications during lactation can result in the transfer of potentially harmful substances into breast milk, posing serious risks to the nursing infant. Consequently, the ability to accurately detect and quantify drugs of abuse in breast milk is critical for clinical toxicology, forensic investigations, and public health monitoring.
This poster outlines a robust and sensitive analytical workflow for the detection of commonly encountered drugs of abuse in human breast milk. Leveraging advanced sample preparation with ISOLUTE® cSPE for QuEChERS and liquid chromatography-tandem mass spectrometry (LC-MS/MS), the method achieves high specificity, low detection limits, and reliable quantification across a range of drug classes. The approach is designed to support laboratories in meeting the growing demand for neonatal safety assessments and maternal substance use evaluations.
Literature number: P281
