Screening of DoA and pesticides in liver following homogenization and SLE
By Biotage
In post-mortem cases, where drugs or pesticides have been used for their poisonous properties, traditional matrices such as urine and whole blood may be inappropriate for qualitative and quantitative analysis. As the site of metabolism for most drugs and toxins, the liver may provide more insight to cause of death than other bodily fluids.
Screening drugs of abuse can be complicated due to the wide variation of functional groups associated with different analyte classes. Most extraction techniques cannot extract all analytes using a single procedure without using non-optimal extraction protocols resulting in compromised extract cleanliness. Supported liquid extraction is a 96-well plate or individual cartridge based extraction technique analogous to traditional liquid-liquid extraction. The technique allows for the simultaneous analysis of cross functional analytes in a single extraction protocol without forfeiting extract cleanliness.
This poster illustrates multiple benefits to laboratory workflow saving both worker hours and consumable costs.
Literature number: P153
