Showing posts tagged with "poster"
Peptide drug discovery programs have advanced to the clinic as the rules for small molecule-like transport and bioavailability have become more thoroughly understood. Macrocyclic peptides, in particul...
Hair analysis is growing in popularity due to the non-invasive nature of the sample collection. Although not used as routinely as other matrices such as blood or urine it does have advantages in that ...
Introduction Concentrations of Vitamin B1 (Thiamine Diphosphate, TDP) and B6 (Pyridoxal-5-Phosphate, PLP) in whole blood are measured clinically to measure various metabolic functions. Accurate concen...
Peptides are well suited for use as tool compounds to interrogate biological systems and processes due to their chameleonic ability to mimic a potential protein partner within the biological system of...
Introduction Whole blood is often the specimen of choice for detection of drugs in the forensic laboratory. Samples are typically extracted to remove interferences and isolate the analytes of interest...
The utility of aminoglycoside antimicrobial additives and foods has recently been challenged due to the effects of bioaccumulation in an animal host. The persistence of these selected residues may res...
Peptide drug discovery efforts are increasing as unbiased screening technologies have improved and strategies to evaluate passive cell permeability have been defined. As a result, the demand for synth...
Catecholamine metabolites vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) are biomarkers for neuroblastoma and catecholamine secreting tumours. We present ...
Urine is a very useful matrix in forensic laboratories, because it is easy to collect and can help determine if a drug has been used recently. There are many viable sample preparation options for urin...
Compliance with GMP is a necessary condition for drug authorization however the scrutiny that it demands can pose local engineering and chemistry issues because process chemists are under increasing p...