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On a scenic drive up the I-15 in southern California, I got to take a tour of the undergraduate lab at California State University, San Marcos with Dr. Robert Iafe. His lab is one of the first to have...
When Isolera™ was launched, the maximum system pressure that could be reached was 10 bars, but reaching that pressure was a challenge since most of the Flash columns could not withstand the higher pre...
Split peaks? Multiple peaks? Are they really a problem? What causes the issue?
Are you observing more chromatographic peaks than you expect compared to TLC or other assessment data? Well, it could be that your method is separating some isomers or, it could be that there is an ac...
Dry loading crude samples for flash purification typically works better than liquid loading, especially for challenging purifications. In this post, I discuss how the ratio of crude sample to dry load...
Learn more about how to get in control of your Flash Purification.
How does flow rate impact my flash column chromatography separation? This is the kind of question I frequently get. After all, we all know that flow rates that are too high or too low can result in ba...
Small changes in method conditions can have a significant impact on flash chromatography performance. In this post we delve into six key factors that impact your purification success in flash column c...
Plate count is a theoretical number describing the separation efficiency of a chromatography column. In short, it is a measure an eluting compound's bandwidth at the time it elutes from a column, Equa...
In all my years of working with medicinal and organic chemists, I have found that choosing how many grams of silica to use for purification by flash chromatography is something frequently guessed at. ...