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Organic reactions are generally inefficient, which means that crude reaction mixtures require work-up and purification to remove by-products and unreacted starting materials and/or catalysts. The goal...
First, join me on a flashback to my past as a discovery chemist just fresh out of grad school and eager to make a difference in pharmaceutical research. I was advised by my boss to model my behavior a...
With synthesizing new molecular entities (NMEs) our mission in life as chemists, we are innovators, creators even. In drug discovery research, these NMEs stand a good chance of becoming a cure for a m...
Chemistry, by its very nature, involves the use of chemicals that can be harmful, toxic and potentially damaging to the environment, which means that drug discovery currently has a large and expensive...
It (almost) doesn’t matter what the intended therapeutic outcome is, for virtually everyone who is working in the business of cannabis processing, CBD / THC remediation proceeds through well recognise...
In this blog, I will address something that is fundamental to years of classic process chemistry techniques. First disclaimer is that the pharma industry uses recrystallization for several purposes, n...
Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question I usually receive, relates to ho...
It’s engrained in our minds and psyche, from earliest school days and exposures to science that heating a reaction speeds it up. Later, we learn some more of the details, that by increasing the temper...
Another excellent question we received following seminars and presentations relates to the function and activity of metal scavengers. IUPAC nomenclature rules combined with various naming systems and ...
Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive ...