Showing posts tagged with "small-molecules-and-synthetic-therapeutics"
Have you ever experienced compound tailing or streaking on your TLC plate or flash chromatography results and wondered what in the world is going on here? Well, there can be multiple reasons for this ...
Compounds precipitating during flash chromatography is at best an inconvenience when working up your crude reaction mixture. Precipitation during purification typically happens in the column or in the...
Up to six compounds can be easily separated with an automated step-gradient optimizer embedded in modern flash chromatography systems.
slash column chromatography has been practiced by chemists since the 1970s. That practice requires the silica in the column be properly wetted to remove trapped gasses and ensure uniform flow (remembe...
On a beautiful sunny day in Chapel Hill, North Carolina, I travelled to the University of North Carolina campus where I spoke with Dr. Alfredo Picado about how using our new Sfär columns has impacted ...
On a scenic drive up the I-15 in southern California, I got to take a tour of the undergraduate lab at California State University, San Marcos with Dr. Robert Iafe. His lab is one of the first to have...
When Isolera™ was launched, the maximum system pressure that could be reached was 10 bars, but reaching that pressure was a challenge since most of the Flash columns could not withstand the higher pre...
Split peaks? Multiple peaks? Are they really a problem? What causes the issue?
Are you observing more chromatographic peaks than you expect compared to TLC or other assessment data? Well, it could be that your method is separating some isomers or, it could be that there is an ac...
Dry loading crude samples for flash purification typically works better than liquid loading, especially for challenging purifications. In this post, I discuss how the ratio of crude sample to dry load...