Scaling-up with Metal Scavengers
Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive ...
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Showing posts tagged with "small-molecules-and-synthetic-therapeutics"
Practical Lab methods for the development of metal removal processes
There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods...
How to Remove Palladium in three easy steps
Removing palladium has become more and more difficult for a number of reasons. Industry is using it more frequently, due to its greener credentials as a catalyst but regulatory bodies are also reducin...
What is metal scavenging and what are metal scavengers?
Whether for pharma, fine chemical, agrochemical, electronic or natural product research, in recent years, there has been increasing pressure to achieve and deliver higher purity products. Chemical pro...
Can biological assay results be trusted if your sample is contaminated with Pd?
I recently read an interesting paper from Graham Wynne and his many collaborators at the University of Oxford and CEMAS describing just how much residual palladium (Pd) is making its way through the s...
Exploding the myth about loading capacity and metal scavengers
Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question we receive usually relates to ho...
Are metal scavengers better than carbon?
After my seminars, I often receive questions from astute attendees on the topic of activated carbon, and how the more modern powerful approach of metal scavenging compares to the traditional applicati...
Why we should be wary of alternatives to the original, trusted Biotage ISOUTE® Si-Thiol metal scavenger
Biotage metal scavengers are widely proven and adopted solutions for the removal of metals such as palladium, from chemical products such as APIs and used in industry thousands of times, the world ove...
Can I use TLC for reversed-phase flash column chromatography method development?
I am often asked why reversed-phase TLC data does not translate well to reversed-phase flash column chromatography. There are several reasons for this and in this post I will attempt to explain the ch...
How do I develop a reversed-phase flash column chromatography method?
Method transfer from reversed-phase TLC (thin layer chromatography) to reversed-phase flash column chromatography can be very challenging. Because of this, I often recommend using HPLC for reversed-ph...